CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus.

Animals Cell Line Cells, Cultured Corticotropin-Releasing Hormone / genetics Hippocampus / cytology Humans Male Mice Mice, Inbred C57BL Neural Stem Cells / cytology Neurogenesis Receptors, Corticotropin-Releasing Hormone / genetics Spatial Memory
BMP4 CRF CRH adult neurogenesis corticotropin-releasing hormone enriched environment exercise hippocampus stem cells stress

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
22 10 2019
Historique:
received: 14 09 2017
revised: 17 01 2018
accepted: 12 09 2019
entrez: 24 10 2019
pubmed: 24 10 2019
medline: 17 9 2020
Statut: ppublish

Résumé

Local cues in the adult neurogenic niches dynamically regulate homeostasis in neural stem cells, whereas their identity and associated molecular mechanisms remain poorly understood. Here, we show that corticotropin-releasing hormone (CRH), the major mediator of mammalian stress response and a key neuromodulator in the adult brain, is necessary for hippocampal neural stem cell (hiNSC) activity under physiological conditions. In particular, we demonstrate functionality of the CRH/CRH receptor (CRHR) system in mouse hiNSCs and conserved expression in humans. Most important, we show that genetic deficiency of CRH impairs hippocampal neurogenesis, affects spatial memory, and compromises hiNSCs' responsiveness to environmental stimuli. These deficits have been partially restored by virus-mediated CRH expression. Additionally, we provide evidence that local disruption of the CRH/CRHR system reduces neurogenesis, while exposure of adult hiNSCs to CRH promotes neurogenic activity via BMP4 suppression. Our findings suggest a critical role of CRH in adult neurogenesis, independently of its stress-related systemic function.

Identifiants

DOI: 10.1016/j.celrep.2019.09.037 PMID: 31644914
pubmed: 31644914
pii: S2211-1247(19)31225-2
doi: 10.1016/j.celrep.2019.09.037
pii:
doi:

Substances chimiques

Receptors, Corticotropin-Releasing Hormone 0
Corticotropin-Releasing Hormone 9015-71-8

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

932-945.e7

Subventions

Organisme : NIDDK NIH HHS
ID : P01 DK033506
Pays : United States

Informations de copyright

Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.

Auteurs

Yassemi Koutmani (Y)

Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece. Electronic address: ykoutmani@bioacademy.gr.

Ioannis A Gampierakis (IA)

Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece.

Alexia Polissidis (A)

Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece.

Methodios Ximerakis (M)

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.

Paraskevi N Koutsoudaki (PN)

Laboratory of Cellular and Molecular Neurobiology, Hellenic Pasteur Institute, Athens 11521, Greece.

Alexandros Polyzos (A)

Center of Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece.

George Agrogiannis (G)

Department of Pathology, University of Athens Medical School, Athens 11527, Greece.

Sevasti Karaliota (S)

Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece.

Dimitra Thomaidou (D)

Laboratory of Cellular and Molecular Neurobiology, Hellenic Pasteur Institute, Athens 11521, Greece.

Lee L Rubin (LL)

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Panagiotis K Politis (PK)

Center of Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece.

Katia P Karalis (KP)

Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece; Endocrine Division, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Emulate, Inc., Boston, MA 02210, USA. Electronic address: katia.karalis@childrens.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › CRH Promotes the Neurogenic Activity of Neural...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › CRH Promotes the Neurogenic Activity of Neural...
questionsmedicales.fr › Cellules › Cellules cultivées › CRH Promotes the Neurogenic Activity of Neural...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Hormones hypothalamiques › Hormones hypophysiotropes libératrices › Corticolibérine › CRH Promotes the Neurogenic Activity of Neural...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › CRH Promotes the Neurogenic Activity of Neural...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › CRH Promotes the Neurogenic Activity of Neural...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › CRH Promotes the Neurogenic Activity of Neural...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › CRH Promotes the Neurogenic Activity of Neural...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches neurales › CRH Promotes the Neurogenic Activity of Neural...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Neurogenèse › CRH Promotes the Neurogenic Activity of Neural...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormones hypothalamiques hypophysotropes régulatrices › Récepteur CRH › CRH Promotes the Neurogenic Activity of Neural...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Mémoire › Mémoire spatiale › CRH Promotes the Neurogenic Activity of Neural...