A green tea-triggered genetic control system for treating diabetes in mice and monkeys.
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
23 10 2019
23 10 2019
Historique:
received:
29
10
2018
revised:
20
05
2019
accepted:
27
08
2019
entrez:
25
10
2019
pubmed:
28
10
2019
medline:
15
9
2020
Statut:
ppublish
Résumé
Cell-based therapies are recognized as the next frontier in medicine, but the translation of many promising technologies into the clinic is currently limited by a lack of remote-control inducers that are safe and can be tightly regulated. Here, we developed therapeutically active engineered cells regulated by a control system that is responsive to protocatechuic acid (PCA), a metabolite found in green tea. We constructed multiple genetic control technologies that could toggle a PCA-responsive ON/OFF switch based on a transcriptional repressor from
Identifiants
pubmed: 31645456
pii: 11/515/eaav8826
doi: 10.1126/scitranslmed.aav8826
pii:
doi:
Substances chimiques
Hydroxybenzoates
0
Tea
0
protocatechuic acid
36R5QJ8L4B
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.