Molecular profiling of primary uveal melanomas with tumor-infiltrating lymphocytes.
T helper cells
chemokines
cytokines
immune suppression
major histocompatibility complex
regulatory T cells
Journal
Oncoimmunology
ISSN: 2162-4011
Titre abrégé: Oncoimmunology
Pays: United States
ID NLM: 101570526
Informations de publication
Date de publication:
Historique:
received:
23
09
2013
revised:
18
02
2014
accepted:
05
06
2014
entrez:
25
10
2019
pubmed:
31
10
2014
medline:
31
10
2014
Statut:
epublish
Résumé
In contrast to other cancers, the presence of tumor-infiltrating lymphocytes (TILs) in uveal melanoma is associated with a poor prognosis. However, how TILs may promote disease progression and what regulates their infiltration has not yet been established. To address these clinically relevant outstanding questions, T cell, immune regulatory, and chemokine gene expression profiles of 57 enucleated uveal melanoma tumors were compared, encompassing 27 with TILs and 30 without,. Tumors with infiltrating lymphocytes expressed more
Identifiants
pubmed: 31646061
doi: 10.4161/21624011.2014.947169
pii: 947169
pmc: PMC6791435
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Pagination
e947169Subventions
Organisme : NCI NIH HHS
ID : R01 CA136776
Pays : United States
Informations de copyright
© 2014 Taylor & Francis Group, LLC.
Références
J Clin Pathol. 2007 Jun;60(6):596-9
pubmed: 16522748
Cancer Res. 2005 Jun 15;65(12):5020-6
pubmed: 15958543
PLoS One. 2011;6(9):e24671
pubmed: 21935436
Nat Immunol. 2001 Feb;2(2):102-7
pubmed: 11175801
Cancer Immunol Immunother. 2007 Oct;56(10):1589-95
pubmed: 17410362
Clin Cancer Res. 2007 Dec 1;13(23):6947-58
pubmed: 18056169
Nat Med. 2007 Mar;13(3):354-60
pubmed: 17334371
J Immunol. 2008 Mar 15;180(6):3766-74
pubmed: 18322182
N Engl J Med. 2003 Jan 16;348(3):203-13
pubmed: 12529460
J Pathol. 2001 Aug;194(4):466-72
pubmed: 11523055
Graefes Arch Clin Exp Ophthalmol. 1996 Jan;234(1):34-42
pubmed: 8750848
Curr Opin Immunol. 2008 Jun;20(3):327-31
pubmed: 18406591
Lancet. 1996 May 4;347(9010):1222-5
pubmed: 8622452
Int J Cancer. 1985 Jul 15;36(1):29-35
pubmed: 3860479
Cancer. 2010 May 1;116(9):2224-33
pubmed: 20209608
Invest Ophthalmol Vis Sci. 2008 Feb;49(2):636-43
pubmed: 18235009
Gut. 2009 Apr;58(4):520-9
pubmed: 19022917
Invest Ophthalmol Vis Sci. 1997 Aug;38(9):1865-72
pubmed: 9286277
Cancer Res. 2009 Apr 1;69(7):3077-85
pubmed: 19293190
Int J Immunopathol Pharmacol. 2006 Jan-Mar;19(1):171-9
pubmed: 16569355
Cancer Res. 2009 Nov 1;69(21):8412-9
pubmed: 19843860
Melanoma Res. 2012 Feb;22(1):98-9
pubmed: 22228277
Blood. 2002 Sep 1;100(5):1551-8
pubmed: 12176869
Front Biosci (Elite Ed). 2010 Jan 01;2:13-21
pubmed: 20036848
Hum Immunol. 2008 Nov;69(11):679-80
pubmed: 19026353
Proc Natl Acad Sci U S A. 2007 May 8;104(19):8029-34
pubmed: 17483450
Blood. 2011 May 19;117(20):5532-40
pubmed: 21422469
Melanoma Res. 2001 Jun;11(3):255-63
pubmed: 11468514
Nat Immunol. 2006 Apr;7(4):354-9
pubmed: 16550198
Trans Am Ophthalmol Soc. 2009 Dec;107:223-8
pubmed: 20126498
Clin Cancer Res. 2008 Aug 15;14(16):5220-7
pubmed: 18698040
Invest Ophthalmol Vis Sci. 2001 Dec;42(13):3081-4
pubmed: 11726606
Cancer Res. 2010 Dec 1;70(23):9538-43
pubmed: 21098713
Am J Clin Pathol. 2002 Oct;118(4):504-11
pubmed: 12375635
Curr Top Microbiol Immunol. 2011;344:269-78
pubmed: 21086108
Invest Ophthalmol Vis Sci. 2001 Sep;42(10):2153-6
pubmed: 11527924
J Biomed Biotechnol. 2010;2010:907092
pubmed: 20634877
Invest Ophthalmol Vis Sci. 1990 Oct;31(10):2106-10
pubmed: 2211008
J Interferon Cytokine Res. 2000 May;20(5):487-98
pubmed: 10841077
Pigment Cell Melanoma Res. 2009 Apr;22(2):175-86
pubmed: 19222802
Invest Ophthalmol Vis Sci. 2012 Oct 01;53(11):6748-55
pubmed: 22930720
J Immunol. 2002 Jul 1;169(1):31-8
pubmed: 12077225
J Immunol. 2000 Oct 15;165(8):4388-96
pubmed: 11035076
Cancer Res. 2005 Apr 15;65(8):3374-9
pubmed: 15833871
Ophthalmic Res. 1992;24(1):20-6
pubmed: 1608588
Cancer Res. 2012 Feb 15;72(4):917-27
pubmed: 22186141
Cancer Immunol Immunother. 2011 Nov;60(11):1529-41
pubmed: 21918895
Curr Biol. 2001 May 1;11(9):691-6
pubmed: 11369232
J Immunol. 2006 Mar 1;176(5):2902-14
pubmed: 16493048
Microsc Res Tech. 2001 Feb 15;52(4):396-400
pubmed: 11170298
Cancer Res. 2003 Dec 1;63(23):8360-5
pubmed: 14678997
Curr Opin Immunol. 2011 Apr;23(2):286-92
pubmed: 21185705
J Immunol. 2008 Jun 15;180(12):8004-10
pubmed: 18523263
Exp Eye Res. 2007 Nov;85(5):617-25
pubmed: 17870068
Cancer. 1990 Jan 1;65(1):112-5
pubmed: 2293857
Invest Ophthalmol Vis Sci. 2012 Aug 09;53(9):5370-8
pubmed: 22743317
Cancer Immunol Immunother. 2011 Aug;60(8):1153-60
pubmed: 21553145