Acute Graft-vs.-Host Disease-Associated Endothelial Activation

Acute Disease Endothelium / metabolism Female Graft vs Host Disease / drug therapy Hematopoietic Stem Cell Transplantation Human Umbilical Vein Endothelial Cells / metabolism Humans Male Polydeoxyribonucleotides / administration & dosage
acute GVHD angiogenesis defibrotide endothelial dysfunction hematopoietic cell transplantation

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2019
Historique:
received: 25 04 2019
accepted: 17 09 2019
entrez: 26 10 2019
pubmed: 28 10 2019
medline: 29 10 2020
Statut: epublish

Résumé

Angiogenesis and endothelial activation and dysfunction have been associated with acute graft-vs.-host disease (aGVHD), pointing to the endothelium as a potential target for pharmacological intervention. Defibrotide (DF) is a drug with an endothelium-protective effect that has been approved for the treatment of veno-occlusive disease/sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation. Clinical data suggest that DF also reduces the incidence of aGVHD; however, the mechanisms of DF-mediated aGVHD regulation have not been examined. To investigate possible DF-mediated prophylactic and therapeutic mechanisms in aGVHD, we performed

Identifiants

DOI: 10.3389/fimmu.2019.02339 PMID: 31649666 PMC: PMC6794443
pubmed: 31649666
doi: 10.3389/fimmu.2019.02339
pmc: PMC6794443
doi:

Substances chimiques

Polydeoxyribonucleotides 0
defibrotide 438HCF2X0M

Types de publication

Clinical Trial Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2339

Informations de copyright

Copyright © 2019 Martinez-Sanchez, Hamelmann, Palomo, Mir, Moreno-Castaño, Torramade, Rovira, Escolar, Cordes, Kalupa, Mertlitz, Riesner, Carreras, Penack and Diaz-Ricart.

Références

Blood. 2010 Mar 11;115(10):1865-72
pubmed: 20042727
Lancet. 2012 Apr 7;379(9823):1301-9
pubmed: 22364685
Vascul Pharmacol. 2013 Jul-Aug;59(1-2):1-10
pubmed: 23680861
Ther Adv Hematol. 2013 Dec;4(6):366-78
pubmed: 24319572
Cancer Biol Ther. 2007 May;6(5):686-90
pubmed: 17495522
Nature. 1995 Aug 17;376(6541):599-602
pubmed: 7637810
Trends Cardiovasc Med. 2006 Feb;16(2):55-9
pubmed: 16473763
Lancet. 2009 May 2;373(9674):1550-61
pubmed: 19282026
Blood. 2014 Jul 17;124(3):363-73
pubmed: 24914140
Dev Cell. 2013 Sep 16;26(5):441-54
pubmed: 24044891
Best Pract Res Clin Haematol. 2008 Jun;21(2):139-48
pubmed: 18503982
Bone Marrow Transplant. 2011 Dec;46(12):1495-502
pubmed: 21460864
Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):541-4
pubmed: 22345588
Biol Blood Marrow Transplant. 2010 Jul;16(7):1005-17
pubmed: 20167278
Bone Marrow Transplant. 2013 May;48(5):715-21
pubmed: 23085826
Blood Res. 2016 Sep;51(3):152-154
pubmed: 27722122
Thromb Haemost. 2018 Jan;118(1):161-173
pubmed: 29304536
Biol Blood Marrow Transplant. 2010 Jul;16(7):985-93
pubmed: 20167280
J Leukoc Biol. 2007 Jan;81(1):176-85
pubmed: 17053165
Blood. 2017 Apr 6;129(14):2021-2032
pubmed: 28096092
Biol Blood Marrow Transplant. 2013 Oct;19(10):1439-45
pubmed: 23845694
Biol Blood Marrow Transplant. 2013 Jan;19(1):22-7
pubmed: 23041600
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Blood. 2005 Nov 1;106(9):3300-7
pubmed: 16002422
Biol Blood Marrow Transplant. 2011 Apr;17(4):497-506
pubmed: 21126597
Transfus Apher Sci. 2016 Feb;54(1):30-4
pubmed: 26922995
Blood. 2008 Nov 15;112(10):4343-52
pubmed: 18711003
Bone Marrow Transplant. 2017 Sep;52(9):1317-1325
pubmed: 28650450
Drug Des Devel Ther. 2016 Aug 16;10:2631-41
pubmed: 27574402
Pediatr Transplant. 2016 Dec;20(8):1132-1136
pubmed: 27734564
Blood Rev. 2015 May;29(3):191-204
pubmed: 25483393
Cell. 2017 Apr 20;169(3):381-405
pubmed: 28431241
J Hematol Oncol. 2016 Oct 20;9(1):113
pubmed: 27765055
Biol Blood Marrow Transplant. 2009 May;15(5):537-46
pubmed: 19361745
J Immunol. 2008 Dec 1;181(11):7581-92
pubmed: 19017947
J Natl Cancer Inst. 2010 Jun 16;102(12):894-908
pubmed: 20463307
Am J Pathol. 2008 Jan;172(1):1-7
pubmed: 18079440
Blood. 2014 Jul 17;124(3):354-62
pubmed: 24914137
Blood. 2013 Sep 12;122(11):1863-72
pubmed: 23878143
Blood. 2011 Apr 21;117(16):4181-9
pubmed: 21258010
Haemostasis. 1986;16 Suppl 1:26-30
pubmed: 3754833
Nat Rev Immunol. 2012 May 11;12(6):443-58
pubmed: 22576252
J Invest Dermatol. 1992 Dec;99(6):683-90
pubmed: 1361507
Blood. 2016 Mar 31;127(13):1719-27
pubmed: 26755708
J Immunol. 2015 Aug 15;195(4):1849-57
pubmed: 26179902
Lancet. 2002 Jun 15;359(9323):2078-83
pubmed: 12086762

Auteurs

Julia Martinez-Sanchez (J)

Josep Carreras Leukaemia Research Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.
Department of Hematopathology, Biomedical Diagnosis Center (CDB), Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.
Barcelona Endothelium Team, Josep Carreras Leukaemia Research Institute, Barcelona, Spain.

Hannah Hamelmann (H)

Hematology, Oncology and Tumor Immunology Department, Charité Universitätsmedizin Berlin, Berlin, Germany.
Berlin-Brandenburg Center for Regenerative Therapies, Charité Medical University of Berlin, Berlin, Germany.
Department of Hematology and Oncology, Berlin Institute of Health, Berlin, Germany.

Marta Palomo (M)

Josep Carreras Leukaemia Research Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.
Department of Hematopathology, Biomedical Diagnosis Center (CDB), Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.
Barcelona Endothelium Team, Josep Carreras Leukaemia Research Institute, Barcelona, Spain.

Enrique Mir (E)

Josep Carreras Leukaemia Research Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.
Department of Hematopathology, Biomedical Diagnosis Center (CDB), Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.
Barcelona Endothelium Team, Josep Carreras Leukaemia Research Institute, Barcelona, Spain.

Ana Belen Moreno-Castaño (AB)

Department of Hematopathology, Biomedical Diagnosis Center (CDB), Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.

Sergi Torramade (S)

Department of Hematopathology, Biomedical Diagnosis Center (CDB), Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.

Montserrat Rovira (M)

Stem Cell Transplantation Unit, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain.

Ginés Escolar (G)

Department of Hematopathology, Biomedical Diagnosis Center (CDB), Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.

Steffen Cordes (S)

Hematology, Oncology and Tumor Immunology Department, Charité Universitätsmedizin Berlin, Berlin, Germany.
Berlin-Brandenburg Center for Regenerative Therapies, Charité Medical University of Berlin, Berlin, Germany.
Department of Hematology and Oncology, Berlin Institute of Health, Berlin, Germany.

Martina Kalupa (M)

Hematology, Oncology and Tumor Immunology Department, Charité Universitätsmedizin Berlin, Berlin, Germany.
Berlin-Brandenburg Center for Regenerative Therapies, Charité Medical University of Berlin, Berlin, Germany.
Department of Hematology and Oncology, Berlin Institute of Health, Berlin, Germany.

Sarah Mertlitz (S)

Hematology, Oncology and Tumor Immunology Department, Charité Universitätsmedizin Berlin, Berlin, Germany.
Berlin-Brandenburg Center for Regenerative Therapies, Charité Medical University of Berlin, Berlin, Germany.
Department of Hematology and Oncology, Berlin Institute of Health, Berlin, Germany.

Katarina Riesner (K)

Hematology, Oncology and Tumor Immunology Department, Charité Universitätsmedizin Berlin, Berlin, Germany.
Berlin-Brandenburg Center for Regenerative Therapies, Charité Medical University of Berlin, Berlin, Germany.
Department of Hematology and Oncology, Berlin Institute of Health, Berlin, Germany.

Enric Carreras (E)

Josep Carreras Leukaemia Research Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.
Barcelona Endothelium Team, Josep Carreras Leukaemia Research Institute, Barcelona, Spain.

Olaf Penack (O)

Hematology, Oncology and Tumor Immunology Department, Charité Universitätsmedizin Berlin, Berlin, Germany.
Berlin-Brandenburg Center for Regenerative Therapies, Charité Medical University of Berlin, Berlin, Germany.
Department of Hematology and Oncology, Berlin Institute of Health, Berlin, Germany.

Maribel Diaz-Ricart (M)

Department of Hematopathology, Biomedical Diagnosis Center (CDB), Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.
Barcelona Endothelium Team, Josep Carreras Leukaemia Research Institute, Barcelona, Spain.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie aigüe › Acute Graft-vs.-Host Disease-Associated...
questionsmedicales.fr › Tissus › Épithélium › Endothélium › Acute Graft-vs.-Host Disease-Associated...
questionsmedicales.fr › Maladies du système immunitaire › Maladie du greffon contre l'hôte › Acute Graft-vs.-Host Disease-Associated...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches hématopoïétiques › Acute Graft-vs.-Host Disease-Associated...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Cellules endothéliales de la veine ombilicale humaine › Acute Graft-vs.-Host Disease-Associated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Acute Graft-vs.-Host Disease-Associated...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Polynucléotides › Polydésoxyribonucléotides › Acute Graft-vs.-Host Disease-Associated...