Cilastatin protects against imipenem-induced nephrotoxicity
BUN, blood urea nitrogen
CKD, chronic kidney disease
CLp, plasma clearance
CLr, renal clearance
CRE, creatinine
Cil, cilastatin
Cilastatin
DDIs, drug-drug interactions
DHP-I, renal dehydropeptidase-I
ES, estrone-3-sulfate
GSH, glutathione
Imipenem
Imp, imipenem
MDA, malonaldehyde
Nephrotoxicity
OATs
OATs, renal organic anion transporters
PAH, p-aminophenol acid
Prb, probenecid
Probenecid
SNP, single nucleotide polymorphism
hOAT, human OAT
hOAT1
hOAT3
rOAT, rat OAT
rPTCs, rabbit primary proximal tubule cells
raOAT, rabbit OAT
t1/2, half life
Journal
Acta pharmaceutica Sinica. B
ISSN: 2211-3835
Titre abrégé: Acta Pharm Sin B
Pays: Netherlands
ID NLM: 101600560
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
02
11
2018
revised:
29
11
2018
accepted:
12
12
2018
entrez:
26
10
2019
pubmed:
28
10
2019
medline:
28
10
2019
Statut:
ppublish
Résumé
Imipenem is a carbapenem antibiotic. However, Imipenem could not be marketed owing to its instability and nephrotoxicity until cilastatin, an inhibitor of renal dehydropeptidase-I (DHP-I), was developed. In present study, the potential roles of renal organic anion transporters (OATs) in alleviating the nephrotoxicity of imipenem by cilastatin were investigated
Identifiants
pubmed: 31649848
doi: 10.1016/j.apsb.2019.02.005
pii: S2211-3835(18)30881-5
pmc: PMC6804466
doi:
Types de publication
Journal Article
Langues
eng
Pagination
986-996Informations de copyright
© 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
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