Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond.
Allopregnanolone
Brexanolone
SGE-217
Steroid enantiomers
Tonic inhibition
Journal
Neurobiology of stress
ISSN: 2352-2895
Titre abrégé: Neurobiol Stress
Pays: United States
ID NLM: 101643409
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
01
08
2019
accepted:
24
09
2019
entrez:
26
10
2019
pubmed:
28
10
2019
medline:
28
10
2019
Statut:
epublish
Résumé
The recent FDA approval of the neurosteroid, brexanolone (allopregnanolone), as a treatment for women with postpartum depression, and successful trials of a related neuroactive steroid, SGE-217, for men and women with major depressive disorder offer the hope of a new era in treating mood and anxiety disorders based on the potential of neurosteroids as modulators of brain function. This review considers potential mechanisms contributing to antidepressant and anxiolytic effects of allopregnanolone and other GABAergic neurosteroids focusing on their actions as positive allosteric modulators of GABA
Identifiants
pubmed: 31649968
doi: 10.1016/j.ynstr.2019.100196
pii: S2352-2895(19)30048-7
pii: 100196
pmc: PMC6804800
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100196Subventions
Organisme : NIMH NIH HHS
ID : R21 MH114866
Pays : United States
Informations de copyright
© 2019 The Author(s).
Déclaration de conflit d'intérêts
CZ and SP are members of the Scientific Advisory Board of Sage Therapeutics and CZ, SP and DC have stock in Sage Therapeutics. Sage Therapeutics was not involved in writing or review of this manuscript.
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