Latent class analysis identifies functional decline with Amsterdam IADL in preclinical Alzheimer's disease.
Alzheimer's disease
Amsterdam-IADL
Autonomy
Latent class analysis
Linear mixed model
Journal
Alzheimer's & dementia (New York, N. Y.)
ISSN: 2352-8737
Titre abrégé: Alzheimers Dement (N Y)
Pays: United States
ID NLM: 101650118
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
26
10
2019
pubmed:
28
10
2019
medline:
28
10
2019
Statut:
epublish
Résumé
Trials in Alzheimer's disease (AD) now include participants at the earliest stages to prevent further decline. However, the lack of tools sensitive to subtle functional changes in early-stage AD hinders the development of new therapies as it is difficult to prove their clinical relevance. We assessed functional changes over three years in 289 elderly memory complainers from the Investigation of Alzheimer's Predictors in subjective memory complainers cohort using the Amsterdam Instrumental-Activities-of-Daily-Living questionnaire (A-IADL-Q). No overall functional decline related to AD imaging markers was evidenced. However, five distinct classes of A-IADL-Q trajectories were identified. The largest class (212 [73.4%]) had stable A-IADL-Q scores over 3 years. A second group (23 [8.0%]) showed a persistent functional decline, higher amyloid load ( The A-IADL-Q identified a subtle functional decline in asymptomatic at-risk AD individuals. This could have important implications in the field of early intervention in AD.
Identifiants
pubmed: 31650012
doi: 10.1016/j.trci.2019.08.009
pii: S2352-8737(19)30060-5
pmc: PMC6804616
doi:
Types de publication
Journal Article
Langues
eng
Pagination
553-562Investigateurs
Hovagim Bakardjian
(H)
Habib Benali
(H)
Hugo Bertin
(H)
Joel Bonheur LaurieBoukadida
(JB)
Nadia Boukerrou
(N)
Enrica Cavedo
(E)
Patrizia Chiesa
(P)
Olivier Colliot
(O)
Bruno Dubois
(B)
Marion Dubois
(M)
Stéphane Epelbaum
(S)
Geoffroy Gagliardi
(G)
Remy Genthon
(R)
Marie-Odile Habert
(MO)
Harald Hampel
(H)
Marion Houot
(M)
Aurélie Kas
(A)
Foudil Lamari
(F)
Marcel Levy
(M)
Simone Lista
(S)
Christiane Metzinger
(C)
Fanny Mochel
(F)
Francis Nyasse
(F)
Catherine Poisson
(C)
Marie-Claude Potier
(MC)
Marie Revillon
(M)
Antonio Santos
(A)
Katia Santos Andrade
(KS)
Marine Sole
(M)
Mohmed Surtee
(M)
Michel Thiebaud de Schotten
(M)
Andrea Vergallo
(A)
Nadjia Younsi
(N)
Informations de copyright
© 2019 The Authors.
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