Trophoblast-derived CXCL12 promotes CD56
Abortion, Habitual
/ immunology
Adult
CD56 Antigen
/ analysis
Cell Adhesion
Cells, Cultured
Chemokine CXCL12
/ physiology
Coculture Techniques
Decidua
/ cytology
Female
Gestational Age
Humans
Immunophenotyping
Integrin beta1
/ analysis
Kangai-1 Protein
/ analysis
Killer Cells, Natural
/ chemistry
Lymphocyte Count
Pregnancy
Stromal Cells
/ cytology
Trophoblasts
/ metabolism
CD29
CD82
CXC12
NK
abortion
adhesion
decidua
trophoblasts
Journal
American journal of reproductive immunology (New York, N.Y. : 1989)
ISSN: 1600-0897
Titre abrégé: Am J Reprod Immunol
Pays: Denmark
ID NLM: 8912860
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
17
07
2019
revised:
22
09
2019
accepted:
22
10
2019
pubmed:
28
10
2019
medline:
31
12
2020
entrez:
26
10
2019
Statut:
ppublish
Résumé
Decidual natural killer (dNK) cells play key roles in maternal-fetal immune regulation, trophoblast invasion, and vascular remodeling, and most dNK cell populations are CD56 A total of 45 women with normal pregnancies and 8 unexplained recurrent spontaneous abortion (RSA) patients were included. We isolated primary human dNK (n = 53) and peripheral blood NK (pNK) cells (n = 5) from specimen and analyzed CD56, CD82, and CD29 by flow cytometry (FCM). We assessed their adhesion ability by cell counts of NK cells adhered to decidual stromal cells (DSCs) in a co-culture system. We found that RSA patients had more CD56 Trophoblast cells enhance the adhesive ability of NK cells to DSCs via the CXCL12/CD82/CD29 signaling pathway and contribute to CD56
Substances chimiques
CD56 Antigen
0
CD82 protein, human
0
CXCL12 protein, human
0
Chemokine CXCL12
0
Integrin beta1
0
Itgb1 protein, human
0
Kangai-1 Protein
0
NCAM1 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Basic Research Program of China
ID : 2015CB943300
Pays : International
Organisme : National Key Research and Development Program of China
ID : 2017YFC1001404
Pays : International
Organisme : National Natural Science Foundation of China
ID : 31671200
Pays : International
Organisme : National Natural Science Foundation of China
ID : 31970798
Pays : International
Organisme : National Natural Science Foundation of China
ID : 81490744
Pays : International
Organisme : National Natural Science Foundation of China
ID : 81671460
Pays : International
Organisme : National Natural Science Foundation of China
ID : 81730039
Pays : International
Organisme : Shanghai Rising-Star Program
ID : 16QA1400800
Pays : International
Organisme : Innovation-oriented Science and Technology Grant from NPFPC Key Laboratory of Reproduction Regulation
ID : CX2017-2
Pays : International
Organisme : Shanghai Municipal Medical and Health Discipline Construction Projects
ID : 2017ZZ02015
Pays : International
Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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