Different patterns of cerebral perfusion in SLE patients with and without neuropsychiatric manifestations.
Adult
Behavioral Symptoms
/ diagnostic imaging
Biomarkers
Cerebrovascular Circulation
/ physiology
Female
Gray Matter
/ diagnostic imaging
Humans
Lupus Erythematosus, Systemic
/ complications
Lupus Vasculitis, Central Nervous System
/ diagnostic imaging
Magnetic Resonance Angiography
Middle Aged
Neuroimaging
Spin Labels
Support Vector Machine
White Matter
/ diagnostic imaging
Young Adult
3D arterial spin labeling
neuropsychiatric systemic lupus erythematosus
perfusion
systemic lupus erythematosus
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
15 02 2020
15 02 2020
Historique:
received:
28
06
2019
revised:
24
09
2019
accepted:
09
10
2019
pubmed:
28
10
2019
medline:
23
7
2021
entrez:
26
10
2019
Statut:
ppublish
Résumé
To investigate brain perfusion patterns in systemic lupus erythematosus (SLE) patients with and without neuropsychiatric systemic lupus erythematosus (NPSLE and non-NPSLE, respectively) and to identify biomarkers for the diagnosis of NPSLE using noninvasive three-dimensional (3D) arterial spin labeling (ASL). Thirty-one NPSLE and 24 non-NPSLE patients and 32 age- and sex-matched normal controls (NCs) were recruited. Three-dimensional ASL-MRI was applied to quantify cerebral perfusion. Whole brain, gray (GM) and white matter (WM), and voxel-based analysis (VBA) were performed to explore perfusion characteristics. Correlation analysis was performed to find the relationship between the perfusion measures, lesion volumes, and clinical variables. Receiver operating characteristic (ROC) analysis and support vector machine (SVM) classification were applied to differentiate NPSLE patients from non-NPSLE patients and healthy controls. Compared to NCs, NPSLE patients showed increased cerebral blood flow (CBF) within WM but decreased CBF within GM, while non-NPSLE patients showed increased CBF within both GM and WM. Compared to non-NPSLE patients, NPSLE patients showed significantly reduced CBF in the frontal gyrus, cerebellum, and corpus callosum. CBF within several brain regions such as cingulate and corpus callosum showed significant correlations with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and the Systemic Lupus International Collaborating Clinics (SLICC) damage index scores. ROC analysis showed moderate performance in distinguishing NPSLE from non-NPSLE patients with AUCs > 0.7, while SVM analysis demonstrated that CBF within the corpus callosum achieved an accuracy of 83.6% in distinguishing NPSLE from non-NPSLE patients. Different brain perfusion patterns were observed between NPSLE and non-NPSLE patients. CBF measured by noninvasive 3D ASL could be a useful biomarker for the diagnosis and disease monitoring of NPSLE and non-NPSLE patients.
Identifiants
pubmed: 31650651
doi: 10.1002/hbm.24837
pmc: PMC7268026
doi:
Substances chimiques
Biomarkers
0
Spin Labels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
755-766Informations de copyright
© 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.
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