Matrix Metalloproteinase-3 is Key Effector of TNF-α-Induced Collagen Degradation in Skin.
cytokines
extracellular matrix
inflammation
interstitial collagens
proteinases
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
22 Oct 2019
22 Oct 2019
Historique:
received:
10
10
2019
accepted:
17
10
2019
entrez:
27
10
2019
pubmed:
28
10
2019
medline:
4
3
2020
Statut:
epublish
Résumé
Inflammatory processes in the skin augment collagen degradation due to the up-regulation of matrix metalloproteinases (MMPs). The aim of the present project was to study the specific impact of MMP-3 on collagen loss in skin and its interplay with the collagenase MMP-13 under inflammatory conditions mimicked by the addition of the pro-inflammatory cytokine tumor necrosis factor-α (TNF-α). Skin explants from MMP-3 knock-out (KO) mice or from transgenic (TG) mice overexpressing MMP-3 in the skin and their respective wild-type counterparts (WT and WTT) were incubated ex vivo for eight days. The rate of collagen degradation, measured by released hydroxyproline, was reduced (
Identifiants
pubmed: 31652545
pii: ijms20205234
doi: 10.3390/ijms20205234
pmc: PMC6829232
pii:
doi:
Substances chimiques
Dipeptides
0
Matrix Metalloproteinase Inhibitors
0
N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide
0
Tumor Necrosis Factor-alpha
0
Collagen
9007-34-5
Matrix Metalloproteinase 13
EC 3.4.24.-
Mmp13 protein, mouse
EC 3.4.24.-
Matrix Metalloproteinase 3
EC 3.4.24.17
Mmp3 protein, mouse
EC 3.4.24.17
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Versus Arthritis
ID : 21447
Pays : United Kingdom
Organisme : European Research Council
ID : 243195
Pays : International
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