Synthesis and Cyclooxygenase Inhibition of Sulfonamide-Substituted (Dihydro)Pyrrolo[3,2,1-
Amides
/ chemistry
Cyclooxygenase 2
/ metabolism
Cyclooxygenase 2 Inhibitors
/ chemical synthesis
Drug Design
Humans
Hydrophobic and Hydrophilic Interactions
Indoles
/ chemical synthesis
Neoplasms
/ diagnostic imaging
Prodrugs
/ chemical synthesis
Structure-Activity Relationship
Sulfonamides
/ chemistry
McMurry cyclization
cancer
imaging
inflammation
lipophilicity
structure-activity-relationship
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
22 Oct 2019
22 Oct 2019
Historique:
received:
26
09
2019
revised:
17
10
2019
accepted:
18
10
2019
entrez:
27
10
2019
pubmed:
28
10
2019
medline:
9
4
2020
Statut:
epublish
Résumé
Non-invasive imaging of cyclooxygenase-2 (COX-2) by radiolabeled ligands is attractive for the diagnosis of cancer, and novel highly affine leads with optimized pharmacokinetic profile are of great interest for future developments. Recent findings have shown that methylsulfonyl-substituted (dihydro)pyrrolo[3,2,1-
Identifiants
pubmed: 31652609
pii: molecules24203807
doi: 10.3390/molecules24203807
pmc: PMC6832141
pii:
doi:
Substances chimiques
Amides
0
Cyclooxygenase 2 Inhibitors
0
Indoles
0
Prodrugs
0
Sulfonamides
0
Cyclooxygenase 2
EC 1.14.99.1
propionamide
QK07G0HP47
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : 59397982
Organisme : Deutsche Forschungsgemeinschaft
ID : 314061271
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