Increased Expression of Adherens Junction Components in Mouse Liver following Bile Duct Ligation.
cadherin
catenin
cholestasis
fibrosis
liver
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
22 10 2019
22 10 2019
Historique:
received:
02
09
2019
revised:
10
10
2019
accepted:
19
10
2019
entrez:
27
10
2019
pubmed:
28
10
2019
medline:
23
9
2020
Statut:
epublish
Résumé
Adherens junctions, consisting of cadherins and catenins, are a group of cell-to-cell junctions that mediate mechanistic linkage between neighboring cells. By doing so, adherens junctions ensure direct intercellular contact and play an indispensable role in maintaining tissue architecture. Considering these critical functions, it is not surprising that adherens junctions are frequently involved in disease. In the present study, the effects of bile duct ligation-a surgical procedure to experimentally induce cholestatic and fibrotic liver pathology-on hepatic adherens junctions were investigated in mice. In essence, it was found that liver mRNA and protein levels of E-cadherin, β-catenin and γ-catenin drastically increase following bile duct ligation. These results could suggest a cytoprotective role for hepatic adherens junctions following bile duct ligation.
Identifiants
pubmed: 31652629
pii: biom9100636
doi: 10.3390/biom9100636
pmc: PMC6843439
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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