A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer.
MAPK
cancer
drug resistance
molecular mechanisms
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
22 Oct 2019
22 Oct 2019
Historique:
received:
19
09
2019
revised:
13
10
2019
accepted:
16
10
2019
entrez:
27
10
2019
pubmed:
28
10
2019
medline:
28
10
2019
Statut:
epublish
Résumé
The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch from extracellular signals to intracellular responses. Alterations of signaling cascades are found in various diseases, including cancer, as a result of genetic and epigenetic changes. Numerous studies focused on both the homeostatic and the pathologic conduct of MAPK signaling; however, there is still much to be deciphered in terms of regulation and action models in both preclinical and clinical research. MAPK has implications in the response to cancer therapy, particularly the activation of the compensatory pathways in response to experimental MAPK inhibition. The present paper discusses new insights into MAPK as a complex cell signaling pathway with roles in the sustenance of cellular normal conduit, response to cancer therapy, and activation of compensatory pathways. Unfortunately, most MAPK inhibitors trigger resistance due to the activation of compensatory feed-back loops in tumor cells and tumor microenvironment components. Therefore, novel combinatorial therapies have to be implemented for cancer management in order to restrict the possibility of alternative pathway activation, as a perspective for developing novel therapies based on integration in translational studies.
Identifiants
pubmed: 31652660
pii: cancers11101618
doi: 10.3390/cancers11101618
pmc: PMC6827047
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare.
Références
Rom J Morphol Embryol. 2011;52(3 Suppl):999-1004
pubmed: 22119816
Oncotarget. 2015 Dec 8;6(39):42183-96
pubmed: 26544513
CPT Pharmacometrics Syst Pharmacol. 2018 Sep;7(9):549-561
pubmed: 30084546
Trends Biochem Sci. 2011 Jun;36(6):320-8
pubmed: 21531565
Eur J Gastroenterol Hepatol. 2012 Mar;24(3):346-7
pubmed: 22266833
Curr Opin Cell Biol. 2012 Oct;24(5):600-6
pubmed: 22980731
J Cell Physiol. 2017 Apr;232(4):862-871
pubmed: 27431052
Pharmacol Ther. 2014 May;142(2):164-75
pubmed: 24333502
N Engl J Med. 2012 Feb 23;366(8):707-14
pubmed: 22356324
J BUON. 2016 Mar-Apr;21(2):349-59
pubmed: 27273944
EMBO J. 1997 Aug 15;16(16):4961-72
pubmed: 9305638
Oncotarget. 2017 Mar 28;8(13):21674-21691
pubmed: 28423510
Sci Signal. 2014 Aug 05;7(337):ra73
pubmed: 25097033
Cancer Manag Res. 2019 Jul 10;11:6457-6466
pubmed: 31372048
Breast. 2013 Dec;22(6):1026-33
pubmed: 24063766
Sci Rep. 2017 Aug 24;7(1):9388
pubmed: 28839232
Drug Des Devel Ther. 2017 Sep 27;11:2871-2890
pubmed: 29033548
Nat Rev Mol Cell Biol. 2015 May;16(5):281-98
pubmed: 25907612
Cancers (Basel). 2018 May 03;10(5):null
pubmed: 29751559
Mol Med Rep. 2019 Feb;19(2):759-770
pubmed: 30535440
Curr Opin Pharmacol. 2012 Aug;12(4):458-63
pubmed: 22401931
Nat Clin Pract Oncol. 2008 May;5(5):280-90
pubmed: 18349857
Am J Transl Res. 2018 Mar 15;10(3):784-795
pubmed: 29636868
Semin Cancer Biol. 2012 Oct;22(5-6):455-61
pubmed: 22627188
P T. 2013 Feb;38(2):96-108
pubmed: 23599677
Prog Cardiovasc Dis. 2012 Jan-Feb;54(4):330-4
pubmed: 22225999
Drug Des Devel Ther. 2015 Mar 16;9:1627-52
pubmed: 25834401
Cell Death Dis. 2017 Oct 12;8(10):e3113
pubmed: 29022891
Nat Commun. 2015 Mar 30;6:6685
pubmed: 25819065
J Gastrointestin Liver Dis. 2015 Jun;24(2):225-34
pubmed: 26114183
Sci Signal. 2011 Mar 29;4(166):pe16
pubmed: 21447797
Biomed Environ Sci. 2013 Nov;26(11):902-11
pubmed: 24331535
J Exp Clin Cancer Res. 2018 Jul 9;37(1):140
pubmed: 29986755
PLoS One. 2017 Jan 30;12(1):e0171157
pubmed: 28135339
Cancer Res. 2016 Jun 1;76(11):3189-99
pubmed: 27197187
J Signal Transduct. 2012;2012:294097
pubmed: 22545213
J Cell Commun Signal. 2017 Dec;11(4):341-356
pubmed: 28357710
World J Gastroenterol. 2014 Aug 7;20(29):9744-58
pubmed: 25110412
Cell Death Dis. 2016 Mar 10;7:e2135
pubmed: 26962685
Nat Med. 2013 Nov;19(11):1423-37
pubmed: 24202395
Target Oncol. 2016 Apr;11(2):183-95
pubmed: 26373299
Cancer Biol Med. 2018 May;15(2):137-156
pubmed: 29951338
Cell. 2010 Jun 25;141(7):1117-34
pubmed: 20602996
Cancer Chemother Pharmacol. 2015 Jan;75(1):183-9
pubmed: 25417902
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14903-8
pubmed: 20668238
Cell Signal. 2018 Oct;50:72-79
pubmed: 29964149
Clin Cancer Res. 2016 Mar 1;22(5):1095-102
pubmed: 26581242
Mol Cell Biochem. 2016 Feb;413(1-2):189-98
pubmed: 26838168
J Cell Physiol. 2016 Dec;231(12):2690-9
pubmed: 26970256
Int J Mol Sci. 2019 Mar 09;20(5):null
pubmed: 30857282
Phytother Res. 2018 Oct;32(10):2009-2020
pubmed: 29952428
Genes Cancer. 2011 Mar;2(3):232-60
pubmed: 21779496
Cancer Res. 2012 Apr 1;72(7):1878-89
pubmed: 22350410
Mol Cancer. 2017 Oct 17;16(1):161
pubmed: 29041978
Biochim Biophys Acta Mol Cell Res. 2019 Jan;1866(1):167-174
pubmed: 30077638
Cancer Res. 2012 Jul 1;72(13):3228-37
pubmed: 22552284
Int J Nanomedicine. 2014 Jul 22;9:3465-79
pubmed: 25092977
Rom J Morphol Embryol. 2011;52(3 Suppl):1005-10
pubmed: 22119817
Nat Prod Bioprospect. 2018 Oct;8(5):335-346
pubmed: 30069678
Cold Spring Harb Perspect Med. 2018 Sep 4;8(9):
pubmed: 29229670
Int J Cancer. 2016 Feb 1;138(3):679-88
pubmed: 26311224
Cancer Res. 2009 May 15;69(10):4286-93
pubmed: 19401449
Acta Odontol Scand. 2015 Apr;73(3):161-8
pubmed: 25598447
Nature. 2017 Oct 5;550(7674):133-136
pubmed: 28953887
Breast Cancer Res Treat. 2010 Jul;122(1):35-43
pubmed: 19701706
Lancet Oncol. 2017 Jul;18(7):863-873
pubmed: 28592387
J Natl Cancer Inst. 2011 Aug 17;103(16):1222-6
pubmed: 21765011
Cancer Cell. 2007 Jul;12(1):9-22
pubmed: 17613433
Mol Cancer. 2018 Feb 19;17(1):53
pubmed: 29455669
Int J Mol Sci. 2018 May 31;19(6):null
pubmed: 29857489
Onco Targets Ther. 2015 Aug 06;8:2053-66
pubmed: 26273208
Cell Biosci. 2011 Dec 28;1:42
pubmed: 22204556
Cancers (Basel). 2019 Apr 30;11(5):null
pubmed: 31052265
J Biol Chem. 2003 Apr 18;278(16):14013-9
pubmed: 12588875
F1000Res. 2017 Aug 31;6:1612
pubmed: 29026524
Target Oncol. 2018 Aug;13(4):437-446
pubmed: 29667105
Exp Biol Med (Maywood). 2015 Apr;240(4):426-37
pubmed: 25304315
Cancer Discov. 2018 Feb;8(2):184-195
pubmed: 29247021
JAKSTAT. 2013 Jul 1;2(3):e24574
pubmed: 24069558
Cancers (Basel). 2018 Jan 19;10(1):null
pubmed: 29351204
Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4321-6
pubmed: 23447565
J Gastrointestin Liver Dis. 2014 Dec;23(4):413-8
pubmed: 25532000
Int J Mol Sci. 2019 May 23;20(10):null
pubmed: 31126017
Oncogene. 2018 Mar;37(13):1775-1787
pubmed: 29348459
Medicina (Kaunas). 2019 Jun 18;55(6):null
pubmed: 31216637
Mol Biol Cell. 1998 Aug;9(8):2185-200
pubmed: 9693375
Cancer Discov. 2014 Jun;4(6):716-29
pubmed: 24670723
Mol Oncol. 2014 Feb;8(1):105-18
pubmed: 24216180
Biotechnol Adv. 2018 Nov 1;36(6):1649-1656
pubmed: 29597027
PLoS One. 2016 Jan 06;11(1):e0146311
pubmed: 26735495
Cancer Discov. 2018 Jan;8(1):20-23
pubmed: 29311225
Cell Cycle. 2013 Aug 15;12(16):2580-97
pubmed: 23860378
Oncogene. 2002 Sep 12;21(41):6356-65
pubmed: 12214276
Biochim Biophys Acta. 2011 Sep;1813(9):1619-33
pubmed: 21167873
Prev Nutr Food Sci. 2017 Dec;22(4):320-326
pubmed: 29333385
Br J Cancer. 2017 Feb 28;116(5):575-583
pubmed: 28152546
Biochim Biophys Acta Gen Subj. 2017 Jul;1861(7):1661-1675
pubmed: 28411077
Arthritis Rheum. 2002 Sep;46(9):2368-76
pubmed: 12355484
Ann Oncol. 2015 May;26(5):894-901
pubmed: 25722381
Acta Derm Venereol. 2015 May;95(5):516-24
pubmed: 25520039
Recent Results Cancer Res. 2018;211:177-186
pubmed: 30069767
Int J Mol Sci. 2016 Apr 15;17(4):573
pubmed: 27092491
Virchows Arch. 2014 Oct;465(4):473-85
pubmed: 25146167
Eur J Cancer. 2017 Sep;83:154-165
pubmed: 28738256
Nature. 2010 Mar 18;464(7287):427-30
pubmed: 20179705
Int J Mol Sci. 2018 May 30;19(6):null
pubmed: 29848992
Oncol Rep. 2017 Nov;38(5):3055-3063
pubmed: 29048617
Clujul Med. 2016;89(3):378-83
pubmed: 27547057
Hypoxia (Auckl). 2015 Dec 11;3:83-92
pubmed: 27774485
Mol Cancer Ther. 2018 Jul;17(7):1526-1539
pubmed: 29654068
Ann Oncol. 2016 Apr;27(4):693-9
pubmed: 26802155
J Cell Mol Med. 2012 Mar;16(3):520-30
pubmed: 21609393
Clin Cancer Res. 2009 Sep 15;15(18):5704-13
pubmed: 19737955
Mol Biol Cell. 2008 Apr;19(4):1391-403
pubmed: 18216281
Curr Pharm Des. 2014;20(42):6565-74
pubmed: 25341933
Oncol Lett. 2016 Jul;12(1):699-706
pubmed: 27347203
J Cell Physiol. 2017 Jun;232(6):1428-1440
pubmed: 27714811
Genes Cancer. 2011 Mar;2(3):344-58
pubmed: 21779504
Nature. 2010 Mar 18;464(7287):431-5
pubmed: 20130576
Acta Pharm Sin B. 2018 Jul;8(4):552-562
pubmed: 30109180
Microbiol Mol Biol Rev. 2011 Mar;75(1):50-83
pubmed: 21372320
Oncogene. 2019 Feb;38(6):852-867
pubmed: 30177840
Cancer Discov. 2014 Oct;4(10):1214-1229
pubmed: 25256614
Cancer Sci. 2018 Oct;109(10):3183-3196
pubmed: 30098066
Lancet Oncol. 2016 Jul;17(7):984-993
pubmed: 27283860
Mol Cancer Ther. 2017 Nov;16(11):2351-2363
pubmed: 28939558
Nat Rev Cancer. 2015 Jul;15(7):409-25
pubmed: 26105538
Biomedicines. 2018 Sep 09;6(3):null
pubmed: 30205595
Lancet Oncol. 2014 Sep;15(10):e461-8
pubmed: 25186049
Eur J Cancer. 2013 Dec;49(18):3936-44
pubmed: 24011934
Mol Cell Biochem. 2013 Sep;381(1-2):61-8
pubmed: 23881244
Sci Rep. 2017 Feb 21;7:43013
pubmed: 28220839
Cancer. 2014 Nov 15;120(22):3446-56
pubmed: 24948110
Cancer. 2012 May 1;118(9):2424-30
pubmed: 21953248
Semin Cancer Biol. 2017 Oct;46:84-106
pubmed: 28676460
Nat Rev Drug Discov. 2010 Nov;9(11):843-56
pubmed: 21031001
Biophys Chem. 2015 Oct;205:24-32
pubmed: 26071843
Cell. 2018 Apr 5;173(2):321-337.e10
pubmed: 29625050
Biomed Pharmacother. 2014 Oct;68(8):1023-9
pubmed: 25443414
PLoS One. 2015 Jun 22;10(6):e0127841
pubmed: 26098947
Int J Oncol. 2017 Dec;51(6):1685-1693
pubmed: 29039514
Cell Death Dis. 2019 May 15;10(6):376
pubmed: 31092814
J Biol Chem. 2016 Jan 22;291(4):1703-18
pubmed: 26565026
Int Immunopharmacol. 2017 Apr;45:110-119
pubmed: 28192731
Oncotarget. 2016 Jan 19;7(3):2532-44
pubmed: 26565813
Int J Mol Sci. 2017 Jun 01;18(6):null
pubmed: 28587155