Articular Cartilage Regeneration in Osteoarthritis.
cartilage
cell-based therapy
gene therapy
osteoarthritis
tissue-based therapy
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
23 10 2019
23 10 2019
Historique:
received:
13
09
2019
revised:
18
10
2019
accepted:
21
10
2019
entrez:
27
10
2019
pubmed:
28
10
2019
medline:
15
8
2020
Statut:
epublish
Résumé
There has been considerable advancement over the last few years in the treatment of osteoarthritis, common chronic disease and a major cause of disability in older adults. In this pathology, the entire joint is involved and the regeneration of articular cartilage still remains one of the main challenges, particularly in an actively inflammatory environment. The recent strategies for osteoarthritis treatment are based on the use of different therapeutic solutions such as cell and gene therapies and tissue engineering. In this review, we provide an overview of current regenerative strategies highlighting the pros and cons, challenges and opportunities, and we try to identify areas where future work should be focused in order to advance this field.
Identifiants
pubmed: 31652798
pii: cells8111305
doi: 10.3390/cells8111305
pmc: PMC6912428
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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