Gender Related Changes in Gene Expression Induced by Valproic Acid in A Mouse Model of Autism and the Correction by S-adenosyl Methionine. Does It Explain the Gender Differences in Autistic Like Behavior?
ASD
SAM
epigenetics
gene expression
mice
nanostring
postnatal VPA injection
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
24 Oct 2019
24 Oct 2019
Historique:
received:
27
09
2019
revised:
21
10
2019
accepted:
22
10
2019
entrez:
27
10
2019
pubmed:
28
10
2019
medline:
7
3
2020
Statut:
epublish
Résumé
In previous studies we produced autism like behavioral changes in mice by Valproic acid (VPA) with significant differences between genders. S-adenosine methionine (SAM) prevented the autism like behavior in both genders. The expression of 770 genes of pathways involved in neurophysiology and neuropathology was studied in the prefrontal cortex of 60 days old male and female mice using the NanoString nCounter. In females, VPA induced statistically significant changes in the expression of 146 genes; 71 genes were upregulated and 75 downregulated. In males, VPA changed the expression of only 19 genes, 16 were upregulated and 3 downregulated. Eight genes were similarly changed in both genders. When considering only the genes that were changed by at least 50%, VPA changed the expression of 15 genes in females and 3 in males. Only Nts was similarly downregulated in both genders. SAM normalized the expression of most changed genes in both genders. We presume that genes that are involved in autism like behavior in our model were similarly changed in both genders and corrected by SAM. The behavioral and other differences between genders may be related to genes that were differently affected by VPA in males and females and/or differently affected by SAM.
Identifiants
pubmed: 31652960
pii: ijms20215278
doi: 10.3390/ijms20215278
pmc: PMC6862653
pii:
doi:
Substances chimiques
Valproic Acid
614OI1Z5WI
S-Adenosylmethionine
7LP2MPO46S
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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