Genome-wide Analyses of Chromatin State in Human Mast Cells Reveal Molecular Drivers and Mediators of Allergic and Inflammatory Diseases.
Biomarkers
Cells, Cultured
Chromatin
/ genetics
Chromatin Assembly and Disassembly
Disease Susceptibility
Fibrinogen
/ genetics
Gene Expression Profiling
Genome-Wide Association Study
Genomics
/ methods
Histones
/ metabolism
Humans
Hypersensitivity
/ etiology
Immunoglobulin E
/ immunology
Inflammation
/ etiology
Mast Cells
/ immunology
Polymorphism, Single Nucleotide
COC domains
SNPs
broad H3K4me3 domains
enhancers
human mast cells
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
19 11 2019
19 11 2019
Historique:
received:
28
02
2018
revised:
18
02
2019
accepted:
25
09
2019
pubmed:
28
10
2019
medline:
23
1
2020
entrez:
27
10
2019
Statut:
ppublish
Résumé
Mast cells (MCs) are versatile immune cells capable of rapidly responding to a diverse range of extracellular cues. Here, we mapped the genomic and transcriptomic changes in human MCs upon diverse stimuli. Our analyses revealed broad H3K4me3 domains and enhancers associated with activation. Notably, the rise of intracellular calcium concentration upon immunoglobulin E (IgE)-mediated crosslinking of the high-affinity IgE receptor (FcεRI) resulted in genome-wide reorganization of the chromatin landscape and was associated with a specific chromatin signature, which we term Ca
Identifiants
pubmed: 31653482
pii: S1074-7613(19)30417-0
doi: 10.1016/j.immuni.2019.09.021
pii:
doi:
Substances chimiques
Biomarkers
0
Chromatin
0
FGL2 protein, human
0
Histones
0
Immunoglobulin E
37341-29-0
Fibrinogen
9001-32-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
949-965.e6Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.