No Association Between AKT1 Polymorphisms and Methamphetamine Addiction in Iranian Population.
AKT1
Methamphetamine
rs2494743
rs2498794
Journal
Journal of molecular neuroscience : MN
ISSN: 1559-1166
Titre abrégé: J Mol Neurosci
Pays: United States
ID NLM: 9002991
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
17
07
2019
accepted:
26
09
2019
pubmed:
28
10
2019
medline:
9
2
2021
entrez:
27
10
2019
Statut:
ppublish
Résumé
Previous studies have shown a high level of heritability for most kinds of substance abuse. Certain single nucleotide polymorphisms (SNPs) or haplotypes have been shown to influence methamphetamine abuse or the related psychosis. Among the most related pathways in dependence to methamphetamine are dopaminergic system-related genes especially V-akt murine thymoma viral oncogene homolog 1 (AKT1). In the current investigation, we genotyped two intronic variants within the AKT1 gene (rs2494743 and rs2498794) in a population of Iranian methamphetamine-dependent individuals and controls. There were no significant differences in alleles, genotypes, or haplotype frequencies of rs2494743 and rs2498794 between cases and controls. Consequently, our study excludes participation of these SNPs in susceptibility to methamphetamine dependence. However, other variants within this gene might affect this trait, so future studies are needed to assess associations between other AKT1 variants and methamphetamine dependence.
Identifiants
pubmed: 31654273
doi: 10.1007/s12031-019-01413-w
pii: 10.1007/s12031-019-01413-w
doi:
Substances chimiques
Methamphetamine
44RAL3456C
AKT1 protein, human
EC 2.7.11.1
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
303-307Références
Arch Gen Psychiatry. 2008 Mar;65(3):345-55
pubmed: 18316681
Mol Psychiatry. 2004 Nov;9(11):981-3
pubmed: 15263908
Behav Genet. 2014 Jan;44(1):1-13
pubmed: 24196977
J Pharmacol Exp Ther. 2009 Jul;330(1):316-25
pubmed: 19364908
Biol Psychiatry. 2004 Nov 1;56(9):698-700
pubmed: 15522255
Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1;126B(1):43-5
pubmed: 15048646
Acta Psychiatr Scand. 1999 May;99(5):368-76
pubmed: 10353453
J Neurochem. 2006 Oct;99(1):277-87
pubmed: 16987250
Science. 1997 Jan 31;275(5300):661-5
pubmed: 9005851
Int J Neuropsychopharmacol. 2006 Feb;9(1):77-81
pubmed: 15982448
PLoS One. 2012;7(8):e42646
pubmed: 22952603
Am J Med Genet B Neuropsychiatr Genet. 2004 Aug 15;129B(1):120-4
pubmed: 15274053
Bioinformatics. 2006 Aug 1;22(15):1928-9
pubmed: 16720584
Trends Neurosci. 1999 Nov;22(11):521-7
pubmed: 10529820
Neurosci Lett. 2003 Mar 13;339(1):5-8
pubmed: 12618287
J Biol Chem. 2004 May 28;279(22):23622-9
pubmed: 15026413
Nat Genet. 2004 Feb;36(2):131-7
pubmed: 14745448
J Psychiatry Neurosci. 2006 Sep;31(5):301-13
pubmed: 16951733
Int J Alzheimers Dis. 2011;2011:762471
pubmed: 21785701
J Psychiatr Res. 2016 Mar;74:22-9
pubmed: 26736037
Biomed Res Int. 2015;2015:316829
pubmed: 26137473
Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5099-104
pubmed: 15044694