The evolving landscape of HPV-related neoplasia in the head and neck.
Biomarkers, Tumor
/ analysis
Cell Transformation, Viral
Cyclin-Dependent Kinase Inhibitor p16
/ analysis
Diagnosis, Differential
Head and Neck Neoplasms
/ epidemiology
Host-Pathogen Interactions
Humans
Papillomaviridae
/ pathogenicity
Papillomavirus Infections
/ diagnosis
Predictive Value of Tests
Prognosis
Squamous Cell Carcinoma of Head and Neck
/ epidemiology
Human papilloma virus
Multiphenotypic sinonasal carcinoma
Oropharyngeal carcinoma
Oropharynx
Squamous cell carcinoma
Journal
Human pathology
ISSN: 1532-8392
Titre abrégé: Hum Pathol
Pays: United States
ID NLM: 9421547
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
22
08
2019
accepted:
09
09
2019
pubmed:
28
10
2019
medline:
9
6
2020
entrez:
27
10
2019
Statut:
ppublish
Résumé
Human papilloma virus (HPV) has emerged as the key etiologic driver in the majority of cancers at head and neck mucosal sites. First described in the uterine cervix and subsequently in oropharyngeal squamous cell carcinomas, the morphologic and clinical spectrum of HPV-related neoplasia has continued to expand and now includes a newly described entity in the sinonasal tract. A recent study has also suggested a role of HPV in some ocular adnexal sebaceous carcinomas. Herein, we review and concisely summarize the spectrum of HPV-driven neoplasia in the head and neck, with a focus on variant morphologies and newly-described entities including key differential diagnoses and clinical implications.
Identifiants
pubmed: 31654690
pii: S0046-8177(19)30166-2
doi: 10.1016/j.humpath.2019.09.001
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
CDKN2A protein, human
0
Cyclin-Dependent Kinase Inhibitor p16
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
29-39Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.