Increased cancer risk in polycystic ovary syndrome: An (un)sympathetic connection?
Dyslipidemias
/ etiology
Estradiol
/ physiology
Female
Forecasting
Humans
Hyperandrogenism
/ etiology
Hyperinsulinism
/ etiology
Incidence
Inflammation
/ etiology
Models, Animal
Models, Biological
Neoplasms
/ epidemiology
Norepinephrine
/ physiology
Polycystic Ovary Syndrome
/ complications
Prevalence
Risk
Sympathetic Nervous System
/ drug effects
Journal
Medical hypotheses
ISSN: 1532-2777
Titre abrégé: Med Hypotheses
Pays: United States
ID NLM: 7505668
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
30
08
2019
accepted:
17
10
2019
pubmed:
28
10
2019
medline:
24
11
2020
entrez:
27
10
2019
Statut:
ppublish
Résumé
Women with polycystic ovary syndrome (PCOS) have been shown to have a higher incidence of cancer. It is suggested that several factors, including hyperinsulinemia, dyslipidemia, raised estrogen levels, chronic inflammation, and reduced apoptosis are responsible for this association. However, in this paper we propose the hypothesis that increased sympathetic activity may represent an important factor that interconnects PCOS and cancer. This hypothesis is based on two facts: a) in women with PCOS is found sympathetic hyperactivity and b) recent data showing a stimulatory effect of the sympathetic system on cancer initiation, progression, and development of metastases. If our hypothesis is correct, then new preventive approaches might be used to reduce cancer risk in women with PCOS.
Identifiants
pubmed: 31655360
pii: S0306-9877(19)30965-X
doi: 10.1016/j.mehy.2019.109437
pii:
doi:
Substances chimiques
Estradiol
4TI98Z838E
Norepinephrine
X4W3ENH1CV
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109437Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.