Effects of the loss of estrogen on the heart's hypertrophic response to chronic left ventricle volume overload in rats.
Aortic valve regurgitation
Cardiac hypertrophy
Estrogens
Left ventricle
Ovariectomy
Rat
Sex dimorphism
Volume overload
Journal
PeerJ
ISSN: 2167-8359
Titre abrégé: PeerJ
Pays: United States
ID NLM: 101603425
Informations de publication
Date de publication:
2019
2019
Historique:
received:
09
07
2019
accepted:
20
09
2019
entrez:
29
10
2019
pubmed:
28
10
2019
medline:
28
10
2019
Statut:
epublish
Résumé
Aortic valve regurgitation (AR) can result in heart failure from chronic overloading of the left ventricle (LV). Little is known of the role of estrogens in the LV responses to this condition. The aim of the study was to compare LV remodeling in female rats with severe AR in absence of estrogens by ovariectomy (Ovx). In a first study, we investigated over 6 months the development of hypertrophy in four groups of female Wistar rats: AR or sham-operated (sham) and Ovx or not. Ovx reduced normal heart growth. As expected, volume overload (VO) from AR resulted in significant LV dilation (42% and 32% increase LV end-diastolic diameter in intact and Ovx groups vs. their respective sham group;
Identifiants
pubmed: 31656705
doi: 10.7717/peerj.7924
pii: 7924
pmc: PMC6812667
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e7924Informations de copyright
©2019 Walsh-Wilkinson et al.
Déclaration de conflit d'intérêts
The authors declare there are no competing interests.
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