Epoxidation is the preferred pathway of first-stage metabolism of abiraterone acetate in brown bullhead (Ameiurus nebulosus).
Abiraterone acetate
Ameiurus nebulosus
Epoxidation
Fish
HPLC/MS
Metabolites
NMR
Journal
Environmental science and pollution research international
ISSN: 1614-7499
Titre abrégé: Environ Sci Pollut Res Int
Pays: Germany
ID NLM: 9441769
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
24
05
2019
accepted:
23
09
2019
pubmed:
28
10
2019
medline:
6
2
2020
entrez:
29
10
2019
Statut:
ppublish
Résumé
Twenty juvenile individuals of brown bullhead (Ameiurus nebulosus), average weight 77 g, were fed by abiraterone acetate prodrug dissolved in olive oil via gastric probe. Dose applied was 3 mg/10 g fish weight. After feeding, they were let out into aquarium and kept there for 3 days. Aquarium water containing excreted metabolites was extracted, and sample was purified and finally analyzed by means of HPLC/MS. Expected both primary (products of hydroxylation) and secondary (products of glucuronidation and sulfatation) metabolites of abiraterone acetate were identified. The NMR measurement of one of the prevailing metabolites presumed to be one of possible hydroxy-abiraterones discovered that it is not hydroxy-abiraterone but abiraterone 16,17-epoxide. Closer analysis of MS
Identifiants
pubmed: 31656995
doi: 10.1007/s11356-019-06568-y
pii: 10.1007/s11356-019-06568-y
doi:
Substances chimiques
Antineoplastic Agents
0
Hydrocarbons, Aromatic
0
Abiraterone Acetate
EM5OCB9YJ6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
34896-34904Subventions
Organisme : ministry of education of the Czech Republic
ID : NPU I Lo1509
Organisme : ministry of education of the Czech Republic
ID : LM2015051
Organisme : ministry of education of the Czech Republic
ID : CZ.02.1.01/0.0/16013/0001761
Organisme : Prague city hall
ID : CZ.2.16/3.1.00/24023
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