The Association of Potassium Status with Parameters of Glucose Metabolism is influenced by Age in Adults.
Adolescent
Adult
Aged
Aged, 80 and over
Aging
/ metabolism
Blood Glucose
/ metabolism
Cross-Sectional Studies
Fasting
/ metabolism
Female
Glucose
/ metabolism
Glycated Hemoglobin
/ metabolism
Humans
Male
Middle Aged
Potassium
/ administration & dosage
Potassium, Dietary
/ administration & dosage
Young Adult
HbA1c
Potassium
age
biochemical status
fasting plasma glucose
intake.
Journal
Endocrine, metabolic & immune disorders drug targets
ISSN: 2212-3873
Titre abrégé: Endocr Metab Immune Disord Drug Targets
Pays: United Arab Emirates
ID NLM: 101269157
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
07
2019
revised:
08
10
2019
accepted:
08
10
2019
pubmed:
29
10
2019
medline:
7
4
2021
entrez:
29
10
2019
Statut:
ppublish
Résumé
Potassium status has been found to affect glucose homeostasis. This study therefore aimed at investigating relationships between potassium status or dietary intake and fasting plasma glucose (FPG) or glycated haemoglobin (HbA1c) in a sample of Austrian adults (18-80 years, n = 421, 61% women) from the Austrian Study on Nutritional Status 2012. Dietary potassium intake was obtained by two 24 h recalls. FPG, plasma K+, and urinary K+ were determined photometrically, HbA1c by HPLC. Associations between the parameters were studied using multiple regression analysis after controlling for confounders and after age stratification of the sample (18-64 y vs. 65-80 y). Most of the participants had a potassium intake of less than the estimated adequate daily intake of 4000 mg/d. In the multiple regression analyses in the whole sample plasma K+ had a statistically significant positive effect on FPG only in the crude model (ß = 0.128, p < 0.01) and on HbA1c also in the fully adjusted model (ß = 0.129, p < 0.05). The small effects on HbA1c were also detected in the younger age group but were absent in the older population. However, in this latter, a reverse association of urinary K+ on HbA1c was observed as well as of dietary potassium intake on FPG with no effects in the younger sample. We suggest that age dependent differences in the association between parameters of potassium status and blood glucose regulation should also be taken into account.
Sections du résumé
BACKGROUND
BACKGROUND
Potassium status has been found to affect glucose homeostasis.
OBJECTIVE
OBJECTIVE
This study therefore aimed at investigating relationships between potassium status or dietary intake and fasting plasma glucose (FPG) or glycated haemoglobin (HbA1c) in a sample of Austrian adults (18-80 years, n = 421, 61% women) from the Austrian Study on Nutritional Status 2012.
METHODS
METHODS
Dietary potassium intake was obtained by two 24 h recalls. FPG, plasma K+, and urinary K+ were determined photometrically, HbA1c by HPLC. Associations between the parameters were studied using multiple regression analysis after controlling for confounders and after age stratification of the sample (18-64 y vs. 65-80 y).
RESULTS
RESULTS
Most of the participants had a potassium intake of less than the estimated adequate daily intake of 4000 mg/d. In the multiple regression analyses in the whole sample plasma K+ had a statistically significant positive effect on FPG only in the crude model (ß = 0.128, p < 0.01) and on HbA1c also in the fully adjusted model (ß = 0.129, p < 0.05). The small effects on HbA1c were also detected in the younger age group but were absent in the older population. However, in this latter, a reverse association of urinary K+ on HbA1c was observed as well as of dietary potassium intake on FPG with no effects in the younger sample.
CONCLUSION
CONCLUSIONS
We suggest that age dependent differences in the association between parameters of potassium status and blood glucose regulation should also be taken into account.
Identifiants
pubmed: 31657684
pii: EMIDDT-EPUB-101939
doi: 10.2174/1871530319666191028100109
doi:
Substances chimiques
Blood Glucose
0
Glycated Hemoglobin A
0
Potassium, Dietary
0
hemoglobin A1c protein, human
0
Glucose
IY9XDZ35W2
Potassium
RWP5GA015D
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
788-796Informations de copyright
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