The effect of temporal adaptation to different temperatures and osmolarities on heat response of TRPV4 in cultured cells.
Activation temperature
Adaptation temperature
Osmolarity
Polymodal receptor
TRPV4
Journal
Journal of thermal biology
ISSN: 0306-4565
Titre abrégé: J Therm Biol
Pays: England
ID NLM: 7600115
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
05
06
2019
revised:
24
09
2019
accepted:
24
09
2019
entrez:
29
10
2019
pubmed:
29
10
2019
medline:
19
3
2020
Statut:
ppublish
Résumé
Transient receptor potential vanilloid 4 (TRPV4) channel is a polymodal receptor activated by moderate heat and hypoosmolarity. TRPV4 expressed in the skin area contributes to several skin functions as a barrier to maintain internal body physiology and a transporter of external stimuli. The skin condition such as skin temperature and osmolarity varies with internal and external changes, and may influence the activity of TRPV4 contributing to skin physiology, thermal sensation, and thermoregulation. However, the combination effect of skin conditions such as temperature and osmolarity on the activity of TRPV4 has not been examined. In the current study, we investigated the effect of temporal adaptation (5-10 min) to different temperature (25-35 °C) and osmolarity (250-350 mOsm) conditions on the heat response (until 40 °C) of human TRPV4 in cultured cells using Ca
Identifiants
pubmed: 31657765
pii: S0306-4565(19)30314-6
doi: 10.1016/j.jtherbio.2019.102424
pii:
doi:
Substances chimiques
TRPV Cation Channels
0
TRPV4 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102424Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.