Dysregulation of Placental Functions and Immune Pathways in Complete Hydatidiform Moles.
choriocarcinoma
galectin
gestational trophoblastic disease
hydatidiform mole
placental-specific gene
systems biology
trophoblast differentiation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Oct 2019
10 Oct 2019
Historique:
received:
17
09
2019
revised:
28
09
2019
accepted:
30
09
2019
entrez:
30
10
2019
pubmed:
30
10
2019
medline:
1
4
2020
Statut:
epublish
Résumé
Gene expression studies of molar pregnancy have been limited to a small number of candidate loci. We analyzed high-dimensional RNA and protein data to characterize molecular features of complete hydatidiform moles (CHMs) and corresponding pathologic pathways. CHMs and first trimester placentas were collected, histopathologically examined, then flash-frozen or paraffin-embedded. Frozen CHMs and control placentas were subjected to RNA-Seq, with resulting data and published placental RNA-Seq data subjected to bioinformatics analyses. Paraffin-embedded tissues from CHMs and control placentas were used for tissue microarray (TMA) construction, immunohistochemistry, and immunoscoring for galectin-14. Of the 14,022 protein-coding genes expressed in all samples, 3,729 were differentially expressed (DE) in CHMs, of which 72% were up-regulated. DE genes were enriched in placenta-specific genes (OR = 1.88,
Identifiants
pubmed: 31658584
pii: ijms20204999
doi: 10.3390/ijms20204999
pmc: PMC6829352
pii:
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Hungarian Scientific Research Fund
ID : K128262
Organisme : Hungarian Scientific Research Fund
ID : K124862
Organisme : Magyar Tudományos Akadémia
ID : Momentum LP2014-7/2014
Organisme : Magyar Tudományos Akadémia
ID : Medinprot Protein Science Research Synergy IV and Adhoc Program grants
Organisme : Magyar Tudományos Akadémia
ID : Premium_2019-436 grant
Organisme : Magyar Tudományos Akadémia
ID : Young Research Fellowships
Organisme : Hungarian National Research, Development and Innovation Office
ID : FIEK_16-1-2016-0005
Organisme : Hungarian Ministry for National Economy
ID : VEKOP-2.3.3-15-2017-0014
Organisme : Gynecologic Oncology Research Fund
ID : USC
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