Reciprocal Modulation of Antiretroviral Drug and Steroid Receptor Function

Anti-Retroviral Agents / adverse effects Cell Line, Tumor Cell Survival / drug effects Humans Inflammation / metabolism Peripheral Blood Stem Cells / drug effects Progestins / metabolism Pyrimidines / adverse effects Receptors, Glucocorticoid / metabolism Receptors, Progesterone / metabolism Receptors, Steroid / metabolism Tenofovir / adverse effects Transcription Factors / metabolism
ARV HIV-1 cell viability dapivirine gene expression inflammation progesterone receptor progestin steroid receptor tenofovir disoproxil fumarate

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
20 12 2019
Historique:
received: 18 09 2019
accepted: 23 10 2019
pubmed: 30 10 2019
medline: 1 9 2020
entrez: 30 10 2019
Statut: epublish

Résumé

Millions of women are exposed simultaneously to antiretroviral drugs (ARVs) and progestin-based hormonal contraceptives. Yet the reciprocal modulation by ARVs and progestins of their intracellular functions is relatively unexplored. We investigated the effects of tenofovir disoproxil fumarate (TDF) and dapivirine (DPV), alone and in the presence of select steroids and progestins, on cell viability, steroid-regulated immunomodulatory gene expression, activation of steroid receptors, and anti-HIV-1 activity

Identifiants

DOI: 10.1128/AAC.01890-19 PMID: 31658973 PMC: PMC7187592
pubmed: 31658973
pii: AAC.01890-19
doi: 10.1128/AAC.01890-19
pmc: PMC7187592
pii:
doi:

Substances chimiques

Anti-Retroviral Agents 0
Progestins 0
Pyrimidines 0
Receptors, Glucocorticoid 0
Receptors, Progesterone 0
Receptors, Steroid 0
TSC22D3 protein, human 0
Transcription Factors 0
Tenofovir 99YXE507IL
Dapivirine TCN4MG2VXS

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NICHD NIH HHS
ID : R01 HD083026
Pays : United States

Informations de copyright

Copyright © 2019 American Society for Microbiology.

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Auteurs

Sigcinile Dlamini (S)

Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.

Michael Kuipa (M)

Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.

Kim Enfield (K)

Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.

Salndave Skosana (S)

Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.

John G Woodland (JG)

Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.

Johnson Mosoko Moliki (JM)

Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.

Alexis J Bick (AJ)

Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.

Zephne van der Spuy (Z)

Department of Obstetrics and Gynaecology, University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa.

Michelle F Maritz (MF)

Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.

Chanel Avenant (C)

Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.

Janet P Hapgood (JP)

Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa janet.hapgood@uct.ac.za.
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Antirétroviraux › Reciprocal Modulation of Antiretroviral Drug...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Reciprocal Modulation of Antiretroviral Drug...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Reciprocal Modulation of Antiretroviral Drug...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Reciprocal Modulation of Antiretroviral Drug...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Reciprocal Modulation of Antiretroviral Drug...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches du sang périphérique › Reciprocal Modulation of Antiretroviral Drug...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Progestines › Reciprocal Modulation of Antiretroviral Drug...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Reciprocal Modulation of Antiretroviral Drug...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs aux glucocorticoïdes › Reciprocal Modulation of Antiretroviral Drug...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs à la progestérone › Reciprocal Modulation of Antiretroviral Drug...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Récepteurs aux stéroïdes › Reciprocal Modulation of Antiretroviral Drug...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Adénine › Ténofovir › Reciprocal Modulation of Antiretroviral Drug...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Reciprocal Modulation of Antiretroviral Drug...