FOXP3 protects conventional human T cells from premature restimulation-induced cell death.
Apoptosis
Autophagy
CD48 Antigen
/ genetics
Cell Death
Forkhead Transcription Factors
/ genetics
Humans
Lymphocyte Activation
Receptors, Antigen, T-Cell
/ genetics
Signal Transduction
Signaling Lymphocytic Activation Molecule Associated Protein
/ genetics
T-Lymphocytes, Regulatory
/ immunology
Tumor Suppressor Protein p53
/ genetics
CD48
FOXP3
RICD
autophagy
conventional T cells
Journal
Cellular & molecular immunology
ISSN: 2042-0226
Titre abrégé: Cell Mol Immunol
Pays: China
ID NLM: 101242872
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
20
05
2019
accepted:
02
10
2019
pubmed:
30
10
2019
medline:
28
12
2021
entrez:
30
10
2019
Statut:
ppublish
Résumé
The adaptive immune response relies on specific apoptotic programs to maintain homeostasis. Conventional effector T cell (Tcon) expansion is constrained by both forkhead box P3 (FOXP3)
Identifiants
pubmed: 31659245
doi: 10.1038/s41423-019-0316-z
pii: 10.1038/s41423-019-0316-z
pmc: PMC7852538
doi:
Substances chimiques
CD48 Antigen
0
CD48 protein, human
0
FOXP3 protein, human
0
Forkhead Transcription Factors
0
Receptors, Antigen, T-Cell
0
SH2D1A protein, human
0
Signaling Lymphocytic Activation Molecule Associated Protein
0
TP53 protein, human
0
Tumor Suppressor Protein p53
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
194-205Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM105821
Pays : United States
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