Stem-cell-derived human microglia transplanted in mouse brain to study human disease.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
22
01
2019
accepted:
26
09
2019
pubmed:
30
10
2019
medline:
1
2
2020
entrez:
30
10
2019
Statut:
ppublish
Résumé
Although genetics highlights the role of microglia in Alzheimer's disease, one-third of putative Alzheimer's disease risk genes lack adequate mouse orthologs. Here we successfully engraft human microglia derived from embryonic stem cells in the mouse brain. The cells recapitulate transcriptionally human primary microglia ex vivo and show expression of human-specific Alzheimer's disease risk genes. Oligomeric amyloid-β induces a divergent response in human versus mouse microglia. This model can be used to study the role of microglia in neurological diseases.
Identifiants
pubmed: 31659342
doi: 10.1038/s41593-019-0525-x
pii: 10.1038/s41593-019-0525-x
doi:
Substances chimiques
Amyloid beta-Peptides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2111-2116Commentaires et corrections
Type : CommentIn
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