Safety of Same-Eye Subretinal Sequential Readministration of
AAV
OCT
RPE65
adeno-associated virus
gene therapy
monkey
non-human primate
readministration
retina
Journal
Molecular therapy. Methods & clinical development
ISSN: 2329-0501
Titre abrégé: Mol Ther Methods Clin Dev
Pays: United States
ID NLM: 101624857
Informations de publication
Date de publication:
13 Dec 2019
13 Dec 2019
Historique:
received:
07
07
2019
accepted:
26
08
2019
entrez:
30
10
2019
pubmed:
30
10
2019
medline:
30
10
2019
Statut:
epublish
Résumé
We have demonstrated safe and effective subretinal readministration of recombinant adeno-associated virus serotype (rAAV) to the contralateral eye in large animals and humans even in the setting of preexisting neutralizing antibodies (NAbs). Readministration of AAV to the same retina may be desirable in order to treat additional areas of the retina not targeted initially or to boost transgene expression levels at a later time point. To better understand the immune and structural consequences of subretinal rAAV readministration to the same eye, we administered bilateral subretinal injections of rAAV2-
Identifiants
pubmed: 31660416
doi: 10.1016/j.omtm.2019.08.011
pii: S2329-0501(19)30091-9
pmc: PMC6807311
doi:
Types de publication
Journal Article
Langues
eng
Pagination
133-148Subventions
Organisme : NEI NIH HHS
ID : P30 EY001583
Pays : United States
Informations de copyright
© 2019 The Authors.
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