Pathophysiology and management of sensitive skin: position paper from the special interest group on sensitive skin of the International Forum for the Study of Itch (IFSI).
Journal
Journal of the European Academy of Dermatology and Venereology : JEADV
ISSN: 1468-3083
Titre abrégé: J Eur Acad Dermatol Venereol
Pays: England
ID NLM: 9216037
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
01
07
2019
accepted:
20
09
2019
pubmed:
30
10
2019
medline:
30
4
2021
entrez:
30
10
2019
Statut:
ppublish
Résumé
The special interest group on sensitive skin of the International Forum for the Study of Itch previously defined sensitive skin as a syndrome defined by the occurrence of unpleasant sensations (stinging, burning, pain, pruritus and tingling sensations) in response to stimuli that normally should not provoke such sensations. This additional paper focuses on the pathophysiology and the management of sensitive skin. Sensitive skin is not an immunological disorder but is related to alterations of the skin nervous system. Skin barrier abnormalities are frequently associated, but there is no cause and direct relationship. Further studies are needed to better understand the pathophysiology of sensitive skin - as well as the inducing factors. Avoidance of possible triggering factors and the use of well-tolerated cosmetics, especially those containing inhibitors of unpleasant sensations, might be suggested for patients with sensitive skin. The role of psychosocial factors, such as stress or negative expectations, might be relevant for subgroups of patients. To date, there is no clinical trial supporting the use of topical or systemic drugs in sensitive skin. The published data are not sufficient to reach a consensus on sensitive skin management. In general, patients with sensitive skin require a personalized approach, taking into account various biomedical, neural and psychosocial factors affecting sensitive skin.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
222-229Investigateurs
Golara Honari
(G)
Christelle Le Gall-Ianotto
(C)
Kenji Takamori
(K)
Renée Richters
(R)
Informations de copyright
© 2019 European Academy of Dermatology and Venereology.
Références
Farage MA. The prevalence of sensitive skin. Front Med 2019; 6: 98.
Misery L, Ständer S, Szepietowski JC et al. Definition of sensitive skin: an expert position paper from the special interest group on sensitive skin of the international forum for the Study of Itch. Acta Derm Venereol 2017; 97: 4-6.
Duarte I, Silveira JEPS, Hafner MFS et al. Sensitive skin: review of an ascending concept. An Bras Dermatol 2017; 92: 521-525.
Misery L. Sensitive skin. Expert Rev Dermatol 2013; 8: 631-637.
Misery L, Loser K, Ständer S. Sensitive skin. J Eur Acad Dermatol Venereol 2016; 30(Suppl 1): 2-8.
Inamadar AC, Palit A. Sensitive skin: an overview. Indian J Dermatol Venereol Leprol 2013; 79: 9-16.
Berardersca E, Farage MA, Maibach H. Sensitive skin: an overview. Int J Cosmet Sci 2011; 35: 2-8.
Richters R, Falcone D, Uzunbajakava N et al. What is sensitive skin ? A systematic literature review of objective measurements. Skin Pharmacol Physiol 2015; 28: 75-83.
Stander S, Schneider SW, Weishaupt C et al. Putative neuronal mechanisms of sensitive skin. Exp Dermatol 2009; 18: 417-423.
Farage MA. Perceptions of sensitive skin: changes in perceived severity and associations with environmental causes. Contact Dermatitis 2008; 59: 226-232.
Farage MA, Katsarou A, Maibach HI. Sensory, clinical and physiological factors in sensitive skin: a review. Contact Dermatitis 2006; 55: 1-14.
Farage MA, Maibach HI. Sensitive skin: closing in a physiological cause. Contact Dermatitis 2010; 62: 137-149.
Maibach HI, Lammintausta K, Berardesca E et al. Tendency to irritation: sensitive skin. J Am Acad Dermatol 1989; 21: 833-835.
Berardesca E, Fluhr JW, Maibach HI. Sensitive Skin Syndrome. Taylor & Francis, New York, NY, 2006.
Honari G, Andersen RM, Maibach HI. Sensitive Skin Syndrome, 2nd edn. CRC Press, Boca Raton, FL, 2017.
Elman SA, Joyce C, Nyberg F et al. Development of classification criteria for discoid lupus erythematosus: results of a Delphi exercise. J Am Acad Dermatol 2017; 77: 261-267.
Diamond IR, Grant RC, Feldman BM et al. Defining consensus: a systematic review recommends methodologic criteria for reporting of Delphi studies. J Clin Epidemiol 2014; 67: 401-409.
Graham B, Regehr G, Wright JG. Delphi as a method to establish consensus for diagnostic criteria. J Clin Epidemiol 2003; 56: 1150-1156.
Angelova-Fischer I. Irritants and Skin Barrier Function. Curr Probl Dermatol 2016; 49: 80-89.
Proksch E, Weidinger S. New insights into the pathogenesis of sensitive skin. Hautarzt 2011; 62: 900-905.
Rerknimitr P, Otsuka A, Nakashima C et al. The etiopathogenesis of atopic dermatitis: barrier disruption, immunological derangement, and pruritus. Inflamm Regen 2017; 37: 14.
Yatagai T, Shimauchi T, Yamaguchi H et al. Sensitive skin is highly frequent in extrinsic atopic dermatitis and correlates with disease severity markers but not necessarily with skin barrier impairment. J Dermatol Sci 2018; 89: 33-39.
Otsuka A, Nomura T, Rerknimitr P et al. The interplay between genetic and environmental factors in the pathogenesis of atopic dermatitis. Immunol Rev 2017; 278: 246-262.
Berardesca E, Cespa M, Farinelli N et al. In vivo transcutaneous penetration of nicotinates and sensitive skin. Contact Dermatitis 1991; 25: 35-38.
Frosch PJ, Kligman AM. A method of apraising the stinging capacity of topically applied substances. J Soc Cosmet Chem 1977; 28: 197-209.
Ohta M, Hikima R, Ogawa T. Physiological characteristics of sensitive skin classified by stinging test. J Cosmet Sci Soc Jpn 2000; 23: 163-167.
Yokota T, Matsumoto M, Sakamaki T et al. Classification of sensitive skin and development of treatment system appropriate for each group. IFSCC Mag 2003; 6: 303-307.
Yamasaki K, Gallo RL. The molecular pathology of rosacea. J Dermatol Sci 2009; 55: 77-81.
Chew A, Maibach H. Sensitive skin. In: Loden M, Maibach H, eds. Dry Skin and Moisturizers: Chemistry and Function. CRC Press, Boca Raton, FL, 2000: 429-440.
Marriott M, Whittle E, Basketter DA. Facial variations in sensory responses. Contact Dermatitis 2003; 49: 227-231.
Distante F, Bonfigli A, Rigano L et al. Intra- and inter-individual differences in facial skin biophysical properties. Cosmet Toilet 2002; 7: 149-158.
Saint-Martory C, Roguedas-Contios AM, Sibaud V et al. Sensitive skin is not limited to the face. Br J Dermatol 2008; 158: 130-133.
Misery L, Rahhali N, Ambonati M et al. Evaluation of sensitive scalp severity and symptomatology by using a new score. J Eur Acad Dermatol Venereol 2011; 25: 1295-1834.
Cho HJ, Chung BY, Lee HB et al. Quantitative study of stratum corneum ceramides contents in patients with sensitive skin. J Dermatol 2012; 39: 295-300.
Kim E, Kim S, Nam GW et al. The alkaline pH-adapted skin barrier is disrupted severely by SLS-induced irritation. Int J Cosmet Sci 2009; 31: 263-269.
Willis CM, Shaw S, de Lacharrière O et al. Sensitive skin: an epidemiological study. Br J Dermatol 2001; 145: 258-263.
Schmitt J, Langan S, Williams HC. What are the best outcome measurements for atopic eczema? A systemic review. J Allergy Clin Immunol 2007; 120: 1389-1398.
Mori T, Ishida K, Mukumoto S et al. Comparison of skin barrier function and sensory nerve electric current perception threshold between IgE-high extrinsic and IgE-normal intrinsic types of atopic dermatitis. Br J Dermatol 2009; 162: 83-90.
Andersen RM, Thyssen JP, Maibach HI. Qualitative vs. quantitative atopic dermatitis criteria - in historical and present perspectives. J Eur Acad Dermatol Venereol 2016; 30: 604-618.
Brenaut E, Barnetche T, Le-Gall Ianotto C et al. Triggering factors in sensitive skin from the worldwide patient's point of view: A systematic literature review and meta-analysis. J Eur Acad Dermatol Venereol 2019. https://doi.org/10.1111/jdv.15985 [Epub ahead of print].
Bernard A, Houssin A, Ficheux AS et al. Consumption of hair dye products by the French women population: usage pattern and exposure assessment. Food Chem Toxicol 2016; 88: 123-132.
Boulais N, Misery L. The epidermis: a sensory tissue. Eur J Dermatol 2008; 18: 119-127.
Caterina MJ, Pang Z. TRP channels in skin biology and pathophysiology. Pharmaceuticals (Basel) 2016; 9: E77.
Kim EJ, Lee DH, Kim YK et al. Adiponectin deficiency contributes to sensitivity in human skin. J Invest Dermatol 2015; 135: 2331-2334.
Saint-Martory C, Sibaud V, Theunis J et al. Arguments for neuropathic pain in sensitive skin. Br J Dermatol 2015; 172: 1120-1121.
Huet F, Dion A, Batardière A et al. Sensitive skin can be small fibre neuropathy: results from a case-control quantitative sensory testing study. Br J Dermatol 2018; 179: 1157-1162.
Misery L, Duboc H, Coffin B et al. Association between two painful and poorly understood conditions: irritable bowel and sensitive skin syndromes. Eur J Pain 2019; 23: 160-166.
Buhé V, Vié K, Guéré C et al. Pathophysiological study of sensitive skin. Acta Derm Venereol 2016; 96: 314-318.
Terkelsen AJ, Karlsson P, Lauria G et al. The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes. Lancet Neurol 2017; 16: 934-944.
Devigili G, Tugnoli V, Penza P et al. The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology. Brain 2008; 131: 1912-1925.
Misery L, Bodéré C, Genestet S et al. Small-fiber neuropathies and skin: news and perspectives for dermatologists. Eur J Dermatol 2013; 24: 147-153.
Seidenari S, Francomano M, Mantavoni L. Baseline biophysical parameters in subjects with sensitive skin. Contact Dermatitis 1998; 38: 311-315.
Roussaki-Schulze AV, Zafiriou E, Nikoulis D et al. Objective biophysical findings in patients with sensitive skin. Drugs Exp Clin Res 2005; 31(Suppl): 17-24.
Wallengren J. Vasoactive peptides in the skin. J Investig Dermatol Symp Proc 1997; 2: 49-55.
Kujala T, Lahti A. Duration of inhibition of non-immunologic immediate contact reactions by acetylsalicylic acid. Contact Dermatitis 1989; 21: 60-61.
Verhoeven EW, de Klerk S, Kraaimaat FW et al. Biopsychosocial mechanisms of chronic itch in patients with skin diseases: a review. Acta Derm Venereol 2008; 88: 211-218.
Colloca L, Finniss D. Nocebo effects, patient-clinician communication, and therapeutic outcomes. JAMA 2012; 307: 567-568.
Schedlowski M, Enck P, Rief W et al. Neuro-bio-behavioral mechanisms of placebo and nocebo responses: implications for clinical trials and clinical practice. Pharmacol Rev 2015; 67: 697-730.
Evers AWM, Colloca L, Blease C et al. Implications of placebo and nocebo effects for clinical practice: expert consensus. Psychother Psychosom 2018; 87: 204-210.
Evers AWM, Peerdeman KJ, Bartels DJP et al. Placebo and nocebo effects on itch: methodological and clinical implications. In: Misery L, Stander S, eds. Pruritus. Springer, London, 2016.
van Laarhoven AIM, Vogelaar ML, Wilder-Smith OH et al. Induction of nocebo and placebo effects on itch and pain by verbal suggestions. Pain 2011; 152: 1486-1494.
Stumpf A, Zerey V, Heuft G et al. Itch perception and skin reactions as modulated by verbal suggestions: role of participant's and investigator's sex. Acta Derm Venereol 2016; 96: 619-623.
Bartels DJP, van Laarhoven AIM, Haverkamp EA et al. Role of conditioning and verbal suggestion in placebo and nocebo effects on itch. PLoS ONE 2014; 9: e91727.
Liccardi G, Senna G, Russo M et al. Evaluation of the nocebo effect during oral challenge in patients with adverse drug reactions. J Investig Allergol Clin Immunol 2004; 14: 104-107.
Bernard A, Ficheux AS, Nedelec AS et al. Induction of sensitive skin and sensitive scalp by hair dyeing. Int J Eng Res Gen Sci 2016; 4: 5.
Kerscher M. Principles of treatment and protection for sensitive skin. Hautarzt 2011; 62: 906-913.
Giménez-Arnau A. Standards for the protection of skin barrier function. Curr Probl Dermatol 2016; 49: 123-124.
Simon D, Nobbe S, Nägeli M et al. Short- and long-term effects of two emollients on itching and skin restoration in xerotic eczema. Dermatol Ther 2018; 2018: e1269.
Berardesca E, Mortillo S, Cameli N et al. Efficacy of a shower cream and a lotion with skin-identical lipids in healthy subjects with atopic dry skin. J Cosmet Dermatol 2018; 17: 477-483.
Weisshaar E. Saving the barrier by prevention. Curr Probl Ddermatol 2016; 49: 152-158.
D'Orazio J, Jarrett S, Amaro-Ortiz A et al. UV radiation and the skin. Int J Mol Sci 2013; 14: 12222-12248.
Dieamant Gde C, Velazquez Pereda Mdel C, Eberlin S et al. Neuroimmunomodulatory compound for sensitive skin care: in vitro and clinical assessment. J Cosmet Dermatol 2008; 7: 112-119.
Lopes DM, McMahon SB. Ultraviolet radiation on the skin: a painful experience? CNS Neurosci Ther 2016; 22: 118-126.
Moyal DD, Fourtanier AM. Broad-spectrum sunscreens provide better protection from solar ultraviolet-simulated radiation and natural sunlight-induced immunosuppression in human beings. J Am Acad Dermatol 2008; 58(Suppl 2): S149-S154.
Reich A, Harupa M, Bury M et al. Application of sunscreen preparations: a need to change the regulations. Photodermatol Photoimmunol Photomed 2009; 25: 242-244.
Misery L. Neuropsychiatric factors in sensitive skin. Clin Dermatol 2017; 35: 281-284.
Bodó E, Kovács I, Telek A et al. Vanilloid receptor-1 (VR1) is widely expressed on various epithelial and mesenchymal cell types of human skin. J Invest Dermatol 2004; 123: 410-413.
Kueper T, Krohn M, Haustedt LO et al. Inhibition of TRPV1 for the treatment of sensitive skin. Exp Dermatol 2010; 19: 980-986.
Fauger A, Lhoste A, Chavagnac-Bonneville M et al. Effects of a new topical combination on sensitive skin. J Cosmet Sci 2015; 66: 79-86.
Choi M, Kim JE, Cho KH et al. In vivo and in vitro analysis of low level light therapy: a useful therapeutic approach for sensitive skin. Lasers Med Sci 2013; 28: 1573-1579.
Sonbol H, Brenaut E, Nowak EML. Efficacy and tolerance tolerability of the phototherapy by with Light Emitting Diodelight-emitting diodes for sensitive skin: a pilot study. Front Med. in revision
Draelos ZD, Levy SB, Lutrario C et al. Evaluation of the performance of a nature-based sensitive skin regimen in subjects with clinically diagnosed sensitive skin. J Drugs Dermatol 2018; 17: 908-913.
Evers AWM. Using the placebo effect: how expectations and learned immune function can optimize dermatological treatments. Exp Dermatol 2017; 26: 18-21.
Colagiuri B, Schenk LA, Kessler MD et al. The placebo effect: from concepts to genes. Neuroscience 2015; 307: 171-190.
Meeuwis SH, Van Middendorp H, Veldhuijzen DS et al. Placebo effects of open-label verbal suggestions on itch. Acta Derm Venereol 2015; 98: 268-274.