Lymph node ratio as a prognostic marker in advanced laryngeal and hypopharyngeal carcinoma after primary total laryngopharyngectomy.
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell
/ diagnosis
Disease-Free Survival
Female
Follow-Up Studies
Humans
Hypopharyngeal Neoplasms
/ diagnosis
Laryngectomy
/ methods
Lymph Node Ratio
Lymph Nodes
/ pathology
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Staging
Pharyngectomy
/ methods
Prognosis
Retrospective Studies
Laryngectomy
advanced larynx and hypopharynx carcinoma
lymph node ratio
oncological outcome
Journal
Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery
ISSN: 1749-4486
Titre abrégé: Clin Otolaryngol
Pays: England
ID NLM: 101247023
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
15
04
2019
revised:
27
09
2019
accepted:
21
10
2019
pubmed:
30
10
2019
medline:
16
6
2021
entrez:
30
10
2019
Statut:
ppublish
Résumé
We evaluated the prognostic value of lymph node ratio (LNR) in patients with advanced laryngeal and hypopharyngeal squamous cell carcinoma. Retrospective chart review. Between 1994 and 2018, 79 patients underwent total laryngopharyngectomy and adjuvant therapy. LNR was determined and statistically compared to patients' overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), locoregional and distant failure. The 5-year OS, DSS and DFS rates were 45.6%, 73.4% and 56.9%, respectively. 24.1% and 25.3% developed loco- regional failure or distant metastatic disease, respectively. Univariate analyses showed that high LNR (cut-off >0.07) was significantly associated with distant and locoregional failure. On multivariate analysis, LNR remained an independent predictor for OS (P = .004), DSS (P = .009) and DFS (P = .044). Increased LNR in patients with advanced laryngeal or hypopharyngeal carcinoma is significantly linked to shortened OS, DSS, DFS and higher locoregional and distant metastatic disease.
Sections du résumé
BACKGROUND
We evaluated the prognostic value of lymph node ratio (LNR) in patients with advanced laryngeal and hypopharyngeal squamous cell carcinoma.
STUDY DESIGN
Retrospective chart review.
METHODS
Between 1994 and 2018, 79 patients underwent total laryngopharyngectomy and adjuvant therapy. LNR was determined and statistically compared to patients' overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), locoregional and distant failure.
RESULTS
The 5-year OS, DSS and DFS rates were 45.6%, 73.4% and 56.9%, respectively. 24.1% and 25.3% developed loco- regional failure or distant metastatic disease, respectively. Univariate analyses showed that high LNR (cut-off >0.07) was significantly associated with distant and locoregional failure. On multivariate analysis, LNR remained an independent predictor for OS (P = .004), DSS (P = .009) and DFS (P = .044).
CONCLUSION
Increased LNR in patients with advanced laryngeal or hypopharyngeal carcinoma is significantly linked to shortened OS, DSS, DFS and higher locoregional and distant metastatic disease.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
73-82Informations de copyright
© 2019 John Wiley & Sons Ltd.
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