High-energy visible light at ambient doses and intensities induces oxidative stress of skin-Protective effects of the antioxidant and Nrf2 inducer Licochalcone A in vitro and in vivo.
antioxidant
licochalcone A
reactive oxygen species
sunscreen
visible light
Journal
Photodermatology, photoimmunology & photomedicine
ISSN: 1600-0781
Titre abrégé: Photodermatol Photoimmunol Photomed
Pays: England
ID NLM: 9013641
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
16
01
2019
revised:
24
09
2019
accepted:
23
10
2019
pubmed:
30
10
2019
medline:
13
11
2020
entrez:
30
10
2019
Statut:
ppublish
Résumé
Solar radiation causes skin damage through the generation of reactive oxygen species (ROS). While UV filters effectively reduce UV-induced ROS, they cannot prevent VIS-induced (400-760 nm) oxidative stress. Therefore, potent antioxidants are needed as additives to sunscreen products. We investigated VIS-induced ROS formation and the photoprotective effects of the Nrf2 inducer Licochalcone A (LicA). Visible spectrum of 400-500 nm dose-dependently induced ROS in cultured human fibroblasts at doses equivalent to 1 hour of sunshine on a sunny summer day (150 J/cm LicA may be a useful additive antioxidant for sunscreens.
Sections du résumé
BACKGROUND
BACKGROUND
Solar radiation causes skin damage through the generation of reactive oxygen species (ROS). While UV filters effectively reduce UV-induced ROS, they cannot prevent VIS-induced (400-760 nm) oxidative stress. Therefore, potent antioxidants are needed as additives to sunscreen products.
METHODS
METHODS
We investigated VIS-induced ROS formation and the photoprotective effects of the Nrf2 inducer Licochalcone A (LicA).
RESULTS
RESULTS
Visible spectrum of 400-500 nm dose-dependently induced ROS in cultured human fibroblasts at doses equivalent to 1 hour of sunshine on a sunny summer day (150 J/cm
CONCLUSION
CONCLUSIONS
LicA may be a useful additive antioxidant for sunscreens.
Identifiants
pubmed: 31661571
doi: 10.1111/phpp.12523
pmc: PMC7078816
doi:
Substances chimiques
Antioxidants
0
Chalcones
0
NF-E2-Related Factor 2
0
NFE2L2 protein, human
0
Sunscreening Agents
0
licochalcone A
JTV5467968
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
135-144Informations de copyright
© 2019 The Authors. Photodermatology, Photoimmunology & Photomedicine published by John Wiley & Sons Ltd.
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