Hair cell maturation is differentially regulated along the tonotopic axis of the mammalian cochlea.
action potentials
auditory
calcium signals
cochlea
development
hair cells
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
23
09
2019
accepted:
24
10
2019
pubmed:
30
10
2019
medline:
9
2
2021
entrez:
30
10
2019
Statut:
ppublish
Résumé
Outer hair cells (OHCs) enhance the sensitivity and the frequency tuning of the mammalian cochlea. Similar to the primary sensory receptor, the inner hair cells (IHCs), the mature functional characteristics of OHCs are acquired before hearing onset. We found that OHCs, like IHCs, fire spontaneous Ca Sound amplification within the mammalian cochlea depends upon specialized hair cells, the outer hair cells (OHCs), which possess both sensory and motile capabilities. In various altricial rodents, OHCs become functionally competent from around postnatal day 7 (P7), before the primary sensory inner hair cells (IHCs), which become competent at about the onset of hearing (P12). The mechanisms responsible for the maturation of OHCs and their synaptic specialization remain poorly understood. We report that spontaneous Ca
Identifiants
pubmed: 31661723
doi: 10.1113/JP279012
pmc: PMC6972525
doi:
Substances chimiques
Cacna1d protein, mouse
0
Calcium Channels, L-Type
0
Large-Conductance Calcium-Activated Potassium Channels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
151-170Subventions
Organisme : NIDCD NIH HHS
ID : K18 DC013304
Pays : United States
Organisme : Medical Research Council
ID : MR/K005561/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102892/Z/13/Z
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.
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