Fatty Acid-Binding Protein 3 is Critical for α-Synuclein Uptake and MPP
1-Methyl-4-phenylpyridinium
/ toxicity
Animals
Biological Transport
Cells, Cultured
Dopamine
/ metabolism
Dopaminergic Neurons
/ cytology
Fatty Acid Binding Protein 3
/ genetics
Mesencephalon
/ metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Mitochondria
/ drug effects
Parkinson Disease
/ metabolism
Reactive Oxygen Species
/ metabolism
Tyrosine 3-Monooxygenase
/ metabolism
alpha-Synuclein
/ metabolism
1-methyl-4-phenylpyridinium (MPP+)
Parkinson’s disease
fatty acid-binding protein 3
mitochondria
synucleinopathy
α-Synuclein
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Oct 2019
28 Oct 2019
Historique:
received:
28
09
2019
revised:
23
10
2019
accepted:
25
10
2019
entrez:
31
10
2019
pubmed:
31
10
2019
medline:
31
3
2020
Statut:
epublish
Résumé
α-Synuclein is an abundant neuronal protein that accumulates in insoluble inclusions in Parkinson's disease and other synucleinopathies. Fatty acids partially regulate α-Synuclein accumulation, and mesencephalic dopaminergic neurons highly express fatty acid-binding protein 3 (FABP3). We previously demonstrated that FABP3 knockout mice show decreased α-Synuclein oligomerization and neuronal degeneration of tyrosine hydroxylase (TH)-positive neurons
Identifiants
pubmed: 31661838
pii: ijms20215358
doi: 10.3390/ijms20215358
pmc: PMC6862506
pii:
doi:
Substances chimiques
Fabp3 protein, mouse
0
Fatty Acid Binding Protein 3
0
Reactive Oxygen Species
0
Snca protein, mouse
0
alpha-Synuclein
0
Tyrosine 3-Monooxygenase
EC 1.14.16.2
1-Methyl-4-phenylpyridinium
R865A5OY8J
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Nat Rev Neurosci. 2013 Jan;14(1):38-48
pubmed: 23254192
Mech Ageing Dev. 2006 Feb;127(2):188-202
pubmed: 16297436
Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4194-9
pubmed: 21325059
Lancet Neurol. 2006 Jun;5(6):525-35
pubmed: 16713924
Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16119-24
pubmed: 22988096
Front Neurosci. 2018 May 23;12:344
pubmed: 29875627
Science. 2016 Sep 30;353(6307):
pubmed: 27708076
J Neuropsychiatry Clin Neurosci. 2002 Spring;14(2):223-36; discussion 222
pubmed: 11983801
Sci Rep. 2019 Feb 11;9(1):1734
pubmed: 30741954
Brain Res. 2019 Mar 15;1707:190-197
pubmed: 30496735
J Biol Chem. 2014 Jul 4;289(27):18957-65
pubmed: 24855640
J Biol Chem. 2001 Nov 9;276(45):41958-62
pubmed: 11553616
Proc Natl Acad Sci U S A. 1998 May 26;95(11):6469-73
pubmed: 9600990
Neuropharmacology. 2019 May 15;150:164-174
pubmed: 30930168
Am J Epidemiol. 2003 Jun 1;157(11):1015-22
pubmed: 12777365
FASEB J. 1999 May;13(8):805-12
pubmed: 10224224
Arch Gen Psychiatry. 2000 Jan;57(1):65-73
pubmed: 10632234
Sci Rep. 2016 Apr 14;6:24526
pubmed: 27075649
EMBO J. 2015 Oct 1;34(19):2408-23
pubmed: 26323479
Stem Cell Reports. 2019 Feb 12;12(2):230-244
pubmed: 30639210
J Neural Transm (Vienna). 2004 Oct;111(10-11):1267-86
pubmed: 15480838
Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9110-5
pubmed: 11481478
J Neural Transm (Vienna). 2009 Dec;116(12):1571-8
pubmed: 19756365
Nature. 2015 Jun 18;522(7556):340-4
pubmed: 26061766
Neuron. 2003 Feb 20;37(4):583-95
pubmed: 12597857
J Mol Biol. 2004 Nov 26;344(3):757-67
pubmed: 15533443
Cytometry A. 2004 Apr;58(2):167-76
pubmed: 15057970
PLoS One. 2019 Mar 22;14(3):e0213663
pubmed: 30901378
Biosci Rep. 2007 Jun;27(1-3):87-104
pubmed: 17486441
Front Neurosci. 2017 Mar 30;11:172
pubmed: 28424577
Hum Mol Genet. 2014 Dec 15;23(24):6495-511
pubmed: 25027319
Int J Mol Sci. 2009 Mar;10(3):724-45
pubmed: 19399218
Nat Neurosci. 2019 Feb;22(2):167-179
pubmed: 30643292
Nat Med. 1998 Nov;4(11):1318-20
pubmed: 9809558
J Neurosci. 1988 Aug;8(8):2804-15
pubmed: 3411354
Methods Mol Biol. 2002;196:31-4
pubmed: 12152210
Neuron. 2003 Sep 11;39(6):889-909
pubmed: 12971891
Nat Rev Neurosci. 2003 May;4(5):365-75
pubmed: 12728264
Biochem Biophys Res Commun. 2015 Sep 11;465(1):53-8
pubmed: 26225746
Circ Res. 1999 Aug 20;85(4):329-37
pubmed: 10455061
Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):650-659
pubmed: 30584104
Neurosci Lett. 1998 Jul 31;251(3):205-8
pubmed: 9726379
Nat Methods. 2014 Oct;11(10):982-4
pubmed: 25264773
J Anat. 1953 Oct;87(4):387-406
pubmed: 13117757