Skeletal muscle as potential central link between sarcopenia and immune senescence.
IL-15
IL-6, IL-7
Immune senescence
Myokines
Sarcopenia
Skeletal muscle
Journal
EBioMedicine
ISSN: 2352-3964
Titre abrégé: EBioMedicine
Pays: Netherlands
ID NLM: 101647039
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
07
08
2019
revised:
30
09
2019
accepted:
17
10
2019
pubmed:
31
10
2019
medline:
1
4
2020
entrez:
31
10
2019
Statut:
ppublish
Résumé
As our population grows older, age-related pathologies are becoming more prevalent. Deterioration of skeletal muscle and the immune system manifests as sarcopenia and immune senescence respectively. The disease burden of these pathologies emphasizes the need for a better understanding of the underlying mechanisms. Skeletal muscle has emerged as a potent regulator of immune system function. As such, skeletal muscle might be the central integrator between sarcopenia and immune senescence in an aging biological system. Therapeutic approaches targeting skeletal muscle might be able to restore both muscle and immune system function. In this review, we therefore outline the current - however still fragmentary - knowledge about the potential communication pathways of muscle and immune system, how they are affected by aging of skeletal muscle and discuss possible treatment strategies. The review intends to be hypothesis-generating and should thereby stimulate further research in this important scientific field.
Identifiants
pubmed: 31662290
pii: S2352-3964(19)30704-2
doi: 10.1016/j.ebiom.2019.10.034
pmc: PMC6945275
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
381-388Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier B.V. All rights reserved.
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