Female reproductive history in relation to chronic obstructive pulmonary disease and lung function in UK biobank: a prospective population-based cohort study.
Adult
Aged
Cohort Studies
Contraceptives, Oral
/ therapeutic use
Estrogen Replacement Therapy
/ statistics & numerical data
Female
Forced Expiratory Volume
Hospitalization
/ statistics & numerical data
Humans
Hysterectomy
/ statistics & numerical data
Linear Models
Lung
/ physiopathology
Menarche
Menopause
Middle Aged
Ovarian Cysts
/ epidemiology
Ovariectomy
/ statistics & numerical data
Parity
Polycystic Ovary Syndrome
/ epidemiology
Proportional Hazards Models
Prospective Studies
Protective Factors
Pulmonary Disease, Chronic Obstructive
/ epidemiology
Reproductive History
Risk Factors
United Kingdom
/ epidemiology
Vital Capacity
chronic obstructive pulmonary disease
hormone replacement therapy
menarche
menopause
oral contraceptives
spirometry
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
28 10 2019
28 10 2019
Historique:
entrez:
31
10
2019
pubmed:
31
10
2019
medline:
21
10
2020
Statut:
epublish
Résumé
Sex differences in respiratory physiology and predilection for developing chronic obstructive pulmonary disease (COPD) have been documented, suggesting that female sex hormones may influence pathogenesis. We investigated whether aspects of female reproductive health might play a role in risk of COPD among women. Population-based prospective cohort study. UK Biobank recruited across 22 centres in the UK between 2006 to 2010. We examined a range of female reproductive health indicators in relation to risk of COPD-related hospitalisation/death (n=271 271) using Cox proportional hazards regression; and lung function (n=273 441) using linear regression. Parity >3 was associated with greater risk of COPD-related hospitalisation/death (adjusted HR 1.45; 95% CI: 1.16 to 1.82) and lower forced expiratory volume at 1 second/forced vital capacity ratio (FEV Multiple female reproductive health indicators across the life course are associated with COPD-related hospitalisation/death and lung function. Further studies are necessary to understand the opposing associations of PCOS/ovarian cysts, HRT and hysterectomy with COPD and objective measures of airway obstruction.
Identifiants
pubmed: 31662371
pii: bmjopen-2019-030318
doi: 10.1136/bmjopen-2019-030318
pmc: PMC6830692
doi:
Substances chimiques
Contraceptives, Oral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e030318Subventions
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M009351/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC/UU/12013/5
Pays : United Kingdom
Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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