The Heterogenicity of Parotid Gland Squamous Cell Carcinoma: A Study of 49 Patients.
Parotid neoplasm
metastases
skin cancer
squamous carcinoma
unknown primary neoplasms
Journal
In vivo (Athens, Greece)
ISSN: 1791-7549
Titre abrégé: In Vivo
Pays: Greece
ID NLM: 8806809
Informations de publication
Date de publication:
Historique:
received:
08
07
2019
revised:
22
07
2019
accepted:
23
07
2019
entrez:
31
10
2019
pubmed:
31
10
2019
medline:
20
3
2020
Statut:
ppublish
Résumé
The aim of this study was to critically evaluate diagnostic workup, treatment and outcome of parotid gland squamous cell carcinoma (SCC). We retrospectively examined 844 consecutive cases of parotid surgery in a German teaching hospital between 1975 and 2017. A total of 748 patients had parotid surgery. A total of 118 patients (15.7%) had a malignant tumour. Of those 49 patients had SCC accounting for 6.6% of all cases, and 41.5% of all malignant tumours. SCC typically affected males (79.6%) of advanced age. A total of 86% of patients had metastatic disease; three cases were primary SCC. Most primary carcinomas were skin (n=26) or pharynx (n=10). Four cases were carcinomas of unknown primary. We performed radical parotidectomy in 47 cases, neck dissections in 42 cases and adjuvant chemo-radiotherapy in 44 cases. The majority of parotid SCC are metastases. In cases without known primary lesion and lack of infiltrative tumour growth, a carcinoma with unknown primary should be considered.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
The aim of this study was to critically evaluate diagnostic workup, treatment and outcome of parotid gland squamous cell carcinoma (SCC).
PATIENTS AND METHODS
METHODS
We retrospectively examined 844 consecutive cases of parotid surgery in a German teaching hospital between 1975 and 2017.
RESULTS
RESULTS
A total of 748 patients had parotid surgery. A total of 118 patients (15.7%) had a malignant tumour. Of those 49 patients had SCC accounting for 6.6% of all cases, and 41.5% of all malignant tumours. SCC typically affected males (79.6%) of advanced age. A total of 86% of patients had metastatic disease; three cases were primary SCC. Most primary carcinomas were skin (n=26) or pharynx (n=10). Four cases were carcinomas of unknown primary. We performed radical parotidectomy in 47 cases, neck dissections in 42 cases and adjuvant chemo-radiotherapy in 44 cases.
CONCLUSION
CONCLUSIONS
The majority of parotid SCC are metastases. In cases without known primary lesion and lack of infiltrative tumour growth, a carcinoma with unknown primary should be considered.
Identifiants
pubmed: 31662530
pii: 33/6/2001
doi: 10.21873/invivo.11696
pmc: PMC6899102
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2001-2006Informations de copyright
Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
Références
Pathol Res Pract. 1986 Dec;181(6):684-92
pubmed: 3562340
Arch Otolaryngol Head Neck Surg. 2005 Jul;131(7):551-5
pubmed: 16027274
Br J Oral Maxillofac Surg. 1998 Feb;36(1):54-7
pubmed: 9578259
Head Neck. 2013 Aug;35(8):1138-43
pubmed: 23152126
Am J Otolaryngol. 2014 Jul-Aug;35(4):469-75
pubmed: 24814339
Head Neck. 2006 Jul;28(7):626-32
pubmed: 16475198
Head Neck. 2006 Sep;28(9):785-91
pubmed: 16783833
Ann Surg Oncol. 1999 Dec;6(8):768-70
pubmed: 10622505
HNO. 1990 Aug;38(8):292-4
pubmed: 2228743
Aust N Z J Surg. 1987 Jan;57(1):23-6
pubmed: 3472508
Head Neck. 2011 Dec;33(12):1789-95
pubmed: 22076982
Head Neck. 2004 Aug;26(8):727-32
pubmed: 15287040
Br J Plast Surg. 1985 Jan;38(1):1-5
pubmed: 3967103
Ann R Coll Surg Engl. 2002 Jan;84(1):1-6
pubmed: 11890618
Laryngoscope. 2003 Jun;113(6):1070-5
pubmed: 12782825
Head Neck. 2015 Jan;37(1):1-7
pubmed: 24339135
Am J Clin Oncol. 2009 Aug;32(4):401-4
pubmed: 19398900
Oral Oncol. 2008 Feb;44(2):187-92
pubmed: 17418612
Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):2899-906
pubmed: 19861510
Acta Otorhinolaryngol Ital. 2017 Aug;37(4):264-269
pubmed: 28872155
Auris Nasus Larynx. 2016 Apr;43(2):187-91
pubmed: 26526643