Acute and Subchronic Oral Toxicity of Fermented Green Tea with Aquilariae Lignum in Rodents.
Journal
Evidence-based complementary and alternative medicine : eCAM
ISSN: 1741-427X
Titre abrégé: Evid Based Complement Alternat Med
Pays: United States
ID NLM: 101215021
Informations de publication
Date de publication:
2019
2019
Historique:
received:
16
05
2019
revised:
28
07
2019
accepted:
23
08
2019
entrez:
31
10
2019
pubmed:
31
10
2019
medline:
31
10
2019
Statut:
epublish
Résumé
Green tea is generally considered safe, but there have been concerns regarding side effects relating to the main component, catechins, especially hepatotoxicities. We have previously shown beneficial effects of fermented green tea with Aquilariae Lignum (fGT) via an oral route in diabetic and obese models. Thus, the toxicological safety of fGT was assessed at limited oral doses for a rodent. Mice or rats of both genders were orally administered distilled water as a control and fGT at 2.0, 1.0, and 0.5 g/kg. There were no mortalities or gross abnormalities in the fGT groups for 2 weeks following the single oral dose in mice. No fGT-relevant abnormalities were found in postmortem and histopathological examinations, suggesting LD
Identifiants
pubmed: 31662782
doi: 10.1155/2019/8721858
pmc: PMC6754909
doi:
Types de publication
Journal Article
Langues
eng
Pagination
8721858Informations de copyright
Copyright © 2019 Sol Lee et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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