Gut microbiome in chronic rheumatic and inflammatory bowel diseases: Similarities and differences.
Adolescent
Adult
Aged
Aged, 80 and over
Child
Chronic Disease
Dysbiosis
/ complications
Female
Gastrointestinal Microbiome
/ genetics
Humans
Inflammation
/ complications
Inflammatory Bowel Diseases
/ microbiology
Intestinal Mucosa
/ immunology
Intestines
/ microbiology
Male
Microbiota
/ genetics
Middle Aged
Rheumatic Diseases
/ microbiology
Young Adult
Inflammatory bowel disease
chronic rheumatic diseases
gut microbiota
immunity
inflammation
Journal
United European gastroenterology journal
ISSN: 2050-6406
Titre abrégé: United European Gastroenterol J
Pays: England
ID NLM: 101606807
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
15
06
2019
accepted:
13
07
2019
entrez:
31
10
2019
pubmed:
31
10
2019
medline:
31
10
2019
Statut:
ppublish
Résumé
Inflammatory bowel diseases (IBDs) and chronic rheumatic diseases (CRDs) are systemic chronic disorders sharing common genetic, immune and environmental factors. About half of patients with IBD develop rheumatic ailments and microscopic intestinal inflammation is present in up to half of CRD patients. IBD and CRD patients also share a common therapeutic armamentarium. Disequilibrium in the complex realm of microbes (known as dysbiosis) that closely interact with the gut mucosal immune system has been associated with both IBD and CRD (spondyloarthritis and rheumatoid arthritis). Whether dysbiosis represents an epiphenomenon or a prodromal feature remains to be determined. In an attempt to further investigate whether specific gut dysbiosis may be the missing link between IBD and CRD in patients developing both diseases, we performed here a systematic literature review focusing on studies looking at bacterial microbiota in CRD and/or IBD patients. We included 80 studies, with a total of 3799 IBD patients without arthritis, 1084 CRD patients without IBD, 132 IBD patients with arthropathy manifestations and 12 spondyloarthritis patients with IBD history. Overall, this systematic review indicates that an increase in Further work is needed to understand the functions of bacteria and of their metabolites but also to characterize fungi and viruses that are commonly found in these patients.
Identifiants
pubmed: 31662859
doi: 10.1177/2050640619867555
pii: 10.1177_2050640619867555
pmc: PMC6794689
doi:
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Pagination
1008-1032Informations de copyright
© Author(s) 2019.
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