Interrelationship between inflammatory cytokines (IL-1, IL-6, IL-33, IL-37) and acquired immunity.
IL-37
IL-6
inflammatory cytokines
innate immunity
Journal
Journal of biological regulators and homeostatic agents
ISSN: 0393-974X
Titre abrégé: J Biol Regul Homeost Agents
Pays: Italy
ID NLM: 8809253
Informations de publication
Date de publication:
Historique:
entrez:
31
10
2019
pubmed:
31
10
2019
medline:
12
11
2019
Statut:
ppublish
Résumé
It is now well-known that interleukins (ILs) play a pivotal role in shaping innate immunity: inflammatory ILs are responsible for all innate aspects of immune response, from the very first vascular reactions to the chronic non-specific response to inflammation; while anti-inflammatory ILs are responsible for keeping adaptive immunity at bay. The interactions between ILs and adaptive immunity have been long considered secondary to the effects on the innate immune system, but in recent years it has appeared more clearly that IL direct interactions with adaptive immunity are extremely important both in physiologic and pathologic immune response. In the present review we analyze the role of inflammatory ILs (IL-1, IL-6, IL-33 and IL-37) on adaptive immunity and briefly discuss the possible therapeutic perspectives of IL-blockade in adaptive immunity disorders.
Identifiants
pubmed: 31663301
doi: 10.23812/Editorial
pii: 53
doi:
Substances chimiques
Cytokines
0
IL33 protein, human
0
IL37 protein, human
0
IL6 protein, human
0
Interleukin-1
0
Interleukin-33
0
Interleukin-6
0
Types de publication
Editorial
Langues
eng
Sous-ensembles de citation
IM
Pagination
1321-1326Informations de copyright
Copyright 2019 Biolife Sas. www.biolifesas.org.