Altered temporal sensitivity in obesity is linked to pro-inflammatory state.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
29 10 2019
29 10 2019
Historique:
received:
02
01
2019
accepted:
23
08
2019
entrez:
31
10
2019
pubmed:
31
10
2019
medline:
20
11
2020
Statut:
epublish
Résumé
Temporal sensitivity to multisensory stimuli has been shown to be reduced in obesity. We sought to investigate the possible role of the pro-inflammatory state on such alteration, considering the effect of the expression of markers, such as leptin and IL6, which are notably high in obesity. The performance of 15 male individuals affected by obesity and 15 normal-weight males was compared using two audiovisual temporal tasks, namely simultaneity judgment and temporal order judgment. Analyses of serum levels of inflammatory markers of leptin and IL6, and of neurotrophic factors of BDNF and S100SB were quantified. At the behavioral level we confirmed previous evidence showing poorer temporal sensitivity in obesity compared to normal-weight participants. Furthermore, leptin, that is a cytokine overexpressed in obesity, represented the best predictor of behavioral differences between groups in both tasks. The hypothesis we put forward is that the immune system, rather than overall cerebral dysfunction, might contribute to explain the altered temporal sensitivity in obesity. The present finding is discussed within the context of the role of cytokines on the brain mechanisms supporting temporal sensitivity.
Identifiants
pubmed: 31664059
doi: 10.1038/s41598-019-51660-5
pii: 10.1038/s41598-019-51660-5
pmc: PMC6820747
doi:
Substances chimiques
Brain-Derived Neurotrophic Factor
0
IL6 protein, human
0
Interleukin-6
0
Leptin
0
S100 Calcium Binding Protein beta Subunit
0
S100B protein, human
0
BDNF protein, human
7171WSG8A2
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
15508Références
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