Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study.
Adolescent
Adult
Aged
Aged, 80 and over
Air Pollutants
/ adverse effects
Air Pollution
/ adverse effects
Asthma
/ chemically induced
Biomarkers
/ blood
Case-Control Studies
Chronic Disease
/ epidemiology
Environmental Exposure
/ adverse effects
Female
Follow-Up Studies
France
/ epidemiology
Humans
Male
Middle Aged
Oxidative Stress
Young Adult
Epidemiology
Fluorescent oxidation products
Mediation analysis
Outdoor air pollution
Oxidative stress
Persistent asthma
Journal
Environmental health : a global access science source
ISSN: 1476-069X
Titre abrégé: Environ Health
Pays: England
ID NLM: 101147645
Informations de publication
Date de publication:
29 10 2019
29 10 2019
Historique:
received:
14
06
2019
accepted:
01
10
2019
entrez:
31
10
2019
pubmed:
31
10
2019
medline:
14
3
2020
Statut:
epublish
Résumé
Evidences that oxidative stress plays a role in the associations between outdoor air pollution and asthma are growing. We aimed to study the role of plasma fluorescent oxidation products levels (FlOPs; an oxidative stress-related biomarker), as potential mediators, in the associations between outdoor air pollution and persistent asthma. Analyses were conducted in 204 adult asthmatics followed up in the French case-control and family study on asthma (EGEA; the Epidemiological study of the Genetic and Environmental factors of Asthma). Persistent asthma was defined as having current asthma at EGEA2 (baseline, 2003-2007) and EGEA3 (follow-up, 2011-2013). Exposures to nitrogen dioxide, nitrogen oxides, road traffic, particulate matter with a diameter ≤ 10 μm (PM FlOPs levels increased with PM Our results add insights on the role of oxidative stress in the association between air pollution and persistent asthma.
Sections du résumé
BACKGROUND
Evidences that oxidative stress plays a role in the associations between outdoor air pollution and asthma are growing. We aimed to study the role of plasma fluorescent oxidation products levels (FlOPs; an oxidative stress-related biomarker), as potential mediators, in the associations between outdoor air pollution and persistent asthma.
METHODS
Analyses were conducted in 204 adult asthmatics followed up in the French case-control and family study on asthma (EGEA; the Epidemiological study of the Genetic and Environmental factors of Asthma). Persistent asthma was defined as having current asthma at EGEA2 (baseline, 2003-2007) and EGEA3 (follow-up, 2011-2013). Exposures to nitrogen dioxide, nitrogen oxides, road traffic, particulate matter with a diameter ≤ 10 μm (PM
RESULTS
FlOPs levels increased with PM
CONCLUSIONS
Our results add insights on the role of oxidative stress in the association between air pollution and persistent asthma.
Identifiants
pubmed: 31665023
doi: 10.1186/s12940-019-0532-0
pii: 10.1186/s12940-019-0532-0
pmc: PMC6819357
doi:
Substances chimiques
Air Pollutants
0
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
90Subventions
Organisme : the National Hospital program of clinical research
ID : PHRC-national 2012, EvAdA
Pays : International
Organisme : ESCAPE
ID : [FP7/2007-2011, Grant Nr.211250].
Pays : International
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