Quantitative Ultrasound Detects Smooth Muscle Activity at the Cervical Internal Os in Vitro.
Cervical assessment
Cervical smooth muscle
Effective scatterer diameter
Internal os architecture
Quantitative ultrasound
Journal
Ultrasound in medicine & biology
ISSN: 1879-291X
Titre abrégé: Ultrasound Med Biol
Pays: England
ID NLM: 0410553
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
19
04
2019
revised:
27
08
2019
accepted:
29
08
2019
pubmed:
2
11
2019
medline:
13
8
2021
entrez:
1
11
2019
Statut:
ppublish
Résumé
The cervix has two biomechanical functions: to remain closed while the fetus develops throughout pregnancy, and to open for delivery of the fetus at full term. This dual function is principally attributed to collagen within the extracellular matrix (ECM). However, recent evidence suggests that other ECM, and non-ECM, components play a role as well. One component is smooth muscle cells arranged circumferentially near the internal os. In this study, we investigate correlations between cervical smooth muscle cell force generation and the effective scatterer diameter (ESD), a quantitative ultrasound parameter directly related to the acoustic impedance distribution and, therefore, a potential biomarker of muscle contractility. Using whole cervical slices (N = 5), we determined significant positive correlations (quantified with Pearson's r) between muscle force generation and ESD immediately after administration of oxytocin (median r = 0.90). In summary, the ESD may prove a useful biomarker for studying structure and function of cervical smooth muscle in vivo.
Identifiants
pubmed: 31668428
pii: S0301-5629(19)31475-9
doi: 10.1016/j.ultrasmedbio.2019.08.020
pmc: PMC6879854
mid: NIHMS1539484
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
149-155Subventions
Organisme : NICHD NIH HHS
ID : R21 HD061896
Pays : United States
Organisme : NICHD NIH HHS
ID : K08 HD088758
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009206
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD082251
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD072077
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD063031
Pays : United States
Informations de copyright
Copyright © 2019 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
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