Coronary artery disease is more severe in patients with primary hyperparathyroidism.
Aged
Calcium
/ blood
Coronary Artery Disease
/ blood
Coronary Vessels
/ diagnostic imaging
Cross-Sectional Studies
Female
Humans
Hyperparathyroidism, Primary
/ blood
Male
Middle Aged
Parathyroid Hormone
/ blood
Parathyroidectomy
/ standards
Patient Selection
Practice Guidelines as Topic
Prospective Studies
Risk Assessment
Risk Factors
Severity of Illness Index
Vascular Calcification
/ blood
Journal
Surgery
ISSN: 1532-7361
Titre abrégé: Surgery
Pays: United States
ID NLM: 0417347
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
30
01
2019
revised:
27
04
2019
accepted:
22
05
2019
pubmed:
2
11
2019
medline:
6
5
2020
entrez:
1
11
2019
Statut:
ppublish
Résumé
Primary hyperparathyroidism is associated with an increased cardiovascular mortality, but mechanisms underlying this association are unclear. The goal of this study was to evaluate coronary artery calcifications via the coronary calcification score in primary hyperparathyroidism patients, to compare with control subjects, and to identify risk factors for high to intermediate risk coronary calcification scores (coronary calcification score >100). Cross-sectional study of primary hyperparathyroidism patients without a history of coronary artery disease, diabetes, or severe, chronic kidney disease. Coronary calcification scores were compared with a cohort of population-based control subjects. The mean coronary calcification score was 120 ± 344 in 130 primary hyperparathyroidism patients. The coronary calcification score was >100 in 27 patients (21%). When compared with control subjects, the percentage of positive coronary calcification scores was similar in primary hyperparathyroidism patients (53% vs 50%); however, positive coronary calcification scores were at the 67 Positive coronary calcification scores were greater in primary hyperparathyroidism patients than in population-based control subjects. These study data may provide new criteria for parathyroidectomy in patients with primary hyperparathyroidism.
Sections du résumé
BACKGROUND
Primary hyperparathyroidism is associated with an increased cardiovascular mortality, but mechanisms underlying this association are unclear. The goal of this study was to evaluate coronary artery calcifications via the coronary calcification score in primary hyperparathyroidism patients, to compare with control subjects, and to identify risk factors for high to intermediate risk coronary calcification scores (coronary calcification score >100).
METHOD
Cross-sectional study of primary hyperparathyroidism patients without a history of coronary artery disease, diabetes, or severe, chronic kidney disease. Coronary calcification scores were compared with a cohort of population-based control subjects.
RESULTS
The mean coronary calcification score was 120 ± 344 in 130 primary hyperparathyroidism patients. The coronary calcification score was >100 in 27 patients (21%). When compared with control subjects, the percentage of positive coronary calcification scores was similar in primary hyperparathyroidism patients (53% vs 50%); however, positive coronary calcification scores were at the 67
CONCLUSION
Positive coronary calcification scores were greater in primary hyperparathyroidism patients than in population-based control subjects. These study data may provide new criteria for parathyroidectomy in patients with primary hyperparathyroidism.
Identifiants
pubmed: 31668778
pii: S0039-6060(19)30612-9
doi: 10.1016/j.surg.2019.05.094
pii:
doi:
Substances chimiques
Parathyroid Hormone
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
149-154Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.