AaHIV a sodium channel scorpion toxin inhibits the proliferation of DU145 prostate cancer cells.
DU145 cells
Proliferation
Prostate cancer
Scorpion peptide
Sodium channel subtypes
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
08 01 2020
08 01 2020
Historique:
received:
26
09
2019
accepted:
13
10
2019
pubmed:
2
11
2019
medline:
28
7
2020
entrez:
1
11
2019
Statut:
ppublish
Résumé
Prostate cancer is the most highly diagnosed cancer in men worldwide. It is characterized by high proliferation, great invasion and metastatic potential. Sodium channel subtypes have been identified as highly expressed in different prostate cancer cell lines. In this study, we have screened the negatively charged fractions of Androctonus australis (Aa) scorpion venom to identify active peptides on DU145 prostate cancer cells proliferation. The most active compound was identified to be the sodium channel peptide AaHIV with an IC
Identifiants
pubmed: 31668811
pii: S0006-291X(19)32017-0
doi: 10.1016/j.bbrc.2019.10.115
pii:
doi:
Substances chimiques
NAV1.6 Voltage-Gated Sodium Channel
0
Scorpion Venoms
0
Sodium Channels
0
scorpion toxin AaHIV
0
scorpion toxin I, Androctonus
12584-90-6
scorpion toxin II, Androctonus
37309-04-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
340-346Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.