A high energy phosphate jump - From pyrophospho-inositol to pyrophospho-serine.
Cell signalling
IP6K
Inositol pyrophosphates
Metabolic messenger
Post-translational modification
Pyrophosphorylation
Journal
Advances in biological regulation
ISSN: 2212-4934
Titre abrégé: Adv Biol Regul
Pays: England
ID NLM: 101572336
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
01
09
2019
revised:
26
09
2019
accepted:
30
09
2019
pubmed:
2
11
2019
medline:
28
1
2021
entrez:
1
11
2019
Statut:
ppublish
Résumé
Inositol pyrophosphates (PP-IPs) are a class of energy rich metabolites present in all eukaryotic cells. The hydroxyl groups on these water soluble derivatives of inositol are substituted with diphosphate and monophosphate moieties. Since the discovery of PP-IPs in the early 1990s, enormous progress has been made in uncovering pleiotropic roles for these small molecules in cellular physiology. PP-IPs exert their effect on proteins in two ways - allosteric regulation by direct binding, or post-translational regulation by serine pyrophosphorylation, a modification unique to PP-IPs. Serine pyrophosphorylation is achieved by Mg
Identifiants
pubmed: 31668836
pii: S2212-4926(19)30083-1
doi: 10.1016/j.jbior.2019.100662
pii:
doi:
Substances chimiques
Diphosphates
0
Inositol Phosphates
0
Serine
452VLY9402
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100662Subventions
Organisme : NCI NIH HHS
ID : R35 CA231998
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE023685
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE024728
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that there are no competing interests associated with the manuscript.