Lipids in the Bone Marrow: An Evolving Perspective.
adipocytes
bone
cholesterol
diet
energy
fat
osteoblasts
Journal
Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170
Informations de publication
Date de publication:
04 02 2020
04 02 2020
Historique:
received:
09
08
2019
revised:
05
09
2019
accepted:
20
09
2019
pubmed:
2
11
2019
medline:
2
6
2021
entrez:
1
11
2019
Statut:
ppublish
Résumé
Because of heavy energy demands to maintain bone homeostasis, the skeletal system is closely tied to whole-body metabolism via neuronal and hormonal mediators. Glucose, amino acids, and fatty acids are the chief fuel sources for bone resident cells during its remodeling. Lipids, which can be mobilized from intracellular depots in the bone marrow, can be a potent source of fatty acids. Thus, while it has been suggested that adipocytes in the bone marrow act as "filler" and are detrimental to skeletal homeostasis, we propose that marrow lipids are, in fact, essential for proper bone functioning. As such, we examine the prevailing evidence regarding the storage, use, and export of lipids within the skeletal niche, including from both in vitro and in vivo model systems. We also highlight the numerous challenges that remain to fully appreciate the relationship of lipid turnover to skeletal homeostasis.
Identifiants
pubmed: 31668874
pii: S1550-4131(19)30518-2
doi: 10.1016/j.cmet.2019.09.015
pmc: PMC7004849
mid: NIHMS1543633
pii:
doi:
Substances chimiques
Fatty Acids
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
219-231Subventions
Organisme : NIDDK NIH HHS
ID : R24 DK092759
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK112374
Pays : United States
Organisme : NIDDK NIH HHS
ID : R56 DK112374
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM115516
Pays : United States
Organisme : NIAMS NIH HHS
ID : K01 AR072123
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
Références
JAMA. 2011 Jun 1;305(21):2184-92
pubmed: 21632482
Sci Rep. 2017 Nov 13;7(1):15376
pubmed: 29133864
Pediatrics. 2007 Mar;119 Suppl 2:S150-62
pubmed: 17332236
Clin Chem Lab Med. 2014 Dec;52(12):1695-727
pubmed: 23940067
Expert Rev Endocrinol Metab. 2009 May;4(3):203-207
pubmed: 30743793
Bone. 1996 Jun;18(6):545-9
pubmed: 8805995
J Cell Physiol. 2019 Jun;234(6):7938-7947
pubmed: 30537019
Mol Cell Biol. 2015 Jun 1;35(11):1979-91
pubmed: 25802278
J Bone Miner Metab. 2013 Sep;31(5):512-9
pubmed: 23588618
Biosci Trends. 2018 Jan 9;11(6):658-666
pubmed: 29269714
Cell. 2015 Sep 10;162(6):1229-41
pubmed: 26321679
Nature. 2014 Sep 4;513(7516):100-4
pubmed: 25043053
Adipocyte. 2017 Jul 3;6(3):250-258
pubmed: 28792783
Diabetes. 2016 Nov;65(11):3225-3232
pubmed: 27959858
Endocrinol Metab Clin North Am. 2017 Mar;46(1):41-50
pubmed: 28131135
Cell Signal. 2016 Mar;28(3):204-213
pubmed: 26724218
Biochem Biophys Res Commun. 1999 Oct 14;264(1):108-11
pubmed: 10527849
Sci Rep. 2018 Nov 7;8(1):16456
pubmed: 30405156
J Bone Miner Res. 2015 Nov;30(11):2058-66
pubmed: 25982922
Osteoporos Int. 2012 Jul;23(7):2053-8
pubmed: 21877200
J Clin Endocrinol Metab. 2013 Dec;98(12):E1999-2005
pubmed: 24106285
J Orthop Surg Res. 2011 Jun 15;6:30
pubmed: 21676245
Diabetes Care. 2006 Jul;29(7):1573-8
pubmed: 16801581
J Bone Miner Res. 2016 Jan;31(1):116-28
pubmed: 26211746
Biophys Rep. 2015;1:90-98
pubmed: 26942223
Scand J Clin Lab Invest. 1995 May;55(3):257-62
pubmed: 7638560
Am J Pathol. 2012 Sep;181(3):928-36
pubmed: 22770664
Cell Stress Chaperones. 2018 Nov;23(6):1283-1294
pubmed: 30194633
Endocr Rev. 2019 Oct 1;40(5):1187-1206
pubmed: 31127816
Bone. 2019 May;122:114-122
pubmed: 30779961
Cell Stem Cell. 2016 Oct 6;19(4):530-543
pubmed: 27524439
J Clin Endocrinol Metab. 2001 Jan;86(1):32-8
pubmed: 11231974
J Bone Miner Metab. 2014 May;32(3):240-51
pubmed: 23925391
Osteoporos Int. 2005 Dec;16(12):1713-20
pubmed: 15940395
Clin Orthop Relat Res. 1965 Jan-Feb;38:157-69
pubmed: 4172974
Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2014;35(1):99-106
pubmed: 24798600
J Biol Chem. 2013 Jun 14;288(24):17432-40
pubmed: 23645674
J Bone Miner Res. 2011 Nov;26(11):2583-96
pubmed: 21713994
J Bone Miner Res. 2018 Jun;33(6):1052-1065
pubmed: 29342317
Cell. 2016 Mar 10;164(6):1248-1256
pubmed: 26967290
Hell J Nucl Med. 2019 Jan-Apr;22(1):2-3
pubmed: 30843001
Bone. 2014 May;62:90-8
pubmed: 24440515
Adv Nutr. 2014 May 14;5(3):217-25
pubmed: 24829468
J Cell Biochem. 2004 Jun 1;92(3):458-71
pubmed: 15156558
PLoS One. 2012;7(9):e46484
pubmed: 23029529
Horm Metab Res. 1997 Nov;29(11):584-91
pubmed: 9479561
J Bone Joint Surg Am. 1985 Jun;67(5):755-63
pubmed: 3997928
Endocrinology. 2014 Jan;155(1):108-16
pubmed: 24169557
Nat Med. 2009 Jul;15(7):757-65
pubmed: 19584867
Biochem Biophys Res Commun. 2001 Jan 26;280(3):874-7
pubmed: 11162604
Eur J Endocrinol. 2019 Mar;180(3):189-199
pubmed: 30566901
Clin Cases Miner Bone Metab. 2008 Jan;5(1):19-34
pubmed: 22460842
Pathol Res Pract. 2004;200(3):231-40
pubmed: 15200275
Atherosclerosis. 2014 Jul;235(1):21-30
pubmed: 24792990
Cell. 2015 Jun 18;161(7):1576-1591
pubmed: 26091038
Cell Metab. 2014 Aug 5;20(2):368-375
pubmed: 24998914
Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11238-E11247
pubmed: 29229807
Leukemia. 2007 Jul;21(7):1580-4
pubmed: 17377589
Am J Physiol Endocrinol Metab. 2010 Dec;299(6):E1096-105
pubmed: 20876761
JCI Insight. 2017 Aug 17;2(16):
pubmed: 28814665
FASEB J. 2019 Feb;33(2):2885-2898
pubmed: 30354669
J Bone Miner Res. 2015 Nov;30(11):2137
pubmed: 26477607
Tex Heart Inst J. 2011;38(2):142-4
pubmed: 21494521
Bone. 2009 Feb;44(2):208-13
pubmed: 18983946
J Biol Chem. 2018 Sep 28;293(39):15055-15069
pubmed: 30082316
Nat Commun. 2018 Nov 16;9(1):4831
pubmed: 30446646
Bone. 2019 Jan;118:32-41
pubmed: 29360620
Eur J Clin Pharmacol. 2012 Jul;68(7):1013-8
pubmed: 22318756
Q Rev Biol. 1996 Dec;71(4):511-48
pubmed: 8987173
Diabetes Care. 2001 Jul;24(7):1192-7
pubmed: 11423501
Mol Cell Endocrinol. 2009 Oct 30;310(1-2):21-9
pubmed: 19376193
Nat Clin Pract Endocrinol Metab. 2009 Mar;5(3):150-9
pubmed: 19229235
Bone. 2019 Jan;118:77-88
pubmed: 29366838
Trends Endocrinol Metab. 2008 Jul;19(5):161-6
pubmed: 18407515
Curr Opin Hematol. 2016 May;23(3):198-205
pubmed: 26871253
Front Endocrinol (Lausanne). 2015 Oct 23;6:165
pubmed: 26557105
J Dent Res. 2012 Mar;91(3):268-74
pubmed: 22180568
Nat Commun. 2015 Aug 06;6:7808
pubmed: 26245716
Annu Rev Nutr. 2007;27:79-101
pubmed: 17313320
Adv Ther. 2008 Jan;25(1):67-76
pubmed: 18264684
Cell Tissue Res. 2007 Jan;327(1):133-41
pubmed: 17024416
J Nutr Metab. 2015;2015:758080
pubmed: 26146567
Biochem Biophys Res Commun. 2014 Jul 18;450(1):777-81
pubmed: 24955854
Endocrinology. 2015 Nov;156(11):4081-93
pubmed: 26327577
PLoS One. 2017 Jun 8;12(6):e0179248
pubmed: 28594896
Int J Mol Sci. 2015 Feb 10;16(2):3831-55
pubmed: 25674855
Annu Rev Pathol. 2011;6:121-45
pubmed: 20936937
Ann Intern Med. 1995 Mar 15;122(6):409-14
pubmed: 7856988
Cancer Growth Metastasis. 2014 Aug 10;7:33-42
pubmed: 25187738
J Bone Miner Res. 2013 Nov;28(11):2414-30
pubmed: 23633228
Bone. 2008 Aug;43(2):230-7
pubmed: 18538644
J Zhejiang Univ Sci B. 2016 Jan;17(1):43-53
pubmed: 26739525
Nat Rev Mol Cell Biol. 2006 May;7(5):373-8
pubmed: 16550215
J Bone Miner Res. 2005 Feb;20(2):283-93
pubmed: 15647823
Expert Rev Cardiovasc Ther. 2011 Mar;9(3):321-8
pubmed: 21438811
Toxicol Pathol. 2017 Oct;45(7):887-893
pubmed: 29096593
Biol Open. 2013 Dec 15;2(12):1382-9
pubmed: 24285710
Biochem J. 1987 Nov 15;248(1):129-37
pubmed: 3325035
J Cell Physiol. 2016 Jun;231(6):1321-33
pubmed: 26519689
J Bone Miner Res. 2014 Apr;29(4):787-95
pubmed: 24123088
Eur J Endocrinol. 2017 Jan;176(1):21-30
pubmed: 27707768
Cell Metab. 2017 Mar 7;25(3):661-672
pubmed: 28162969
Am J Pathol. 2016 Nov;186(11):3054-3063
pubmed: 27648615
Alcohol Alcohol. 2012 Jul-Aug;47(4):413-22
pubmed: 22596044
J Clin Endocrinol Metab. 2009 Jun;94(6):2129-36
pubmed: 19318450
J Bone Miner Res. 2018 Jun;33(6):1154-1165
pubmed: 29444341
J Cell Physiol. 2015 Sep;230(9):2032-7
pubmed: 25663195
Physiol Rev. 2017 Apr;97(2):667-698
pubmed: 28202599
J Biol Chem. 2012 Jun 1;287(23):19229-41
pubmed: 22500026
Clin Orthop Relat Res. 2003 May;(410):213-24
pubmed: 12771833
J Appl Physiol (1985). 2016 Apr 15;120(8):947-55
pubmed: 26769956
Nutr Res. 2010 Mar;30(3):191-9
pubmed: 20417880
Gene. 2011 May 15;477(1-2):1-11
pubmed: 21241784
Annu Rev Nutr. 2015;35:265-94
pubmed: 25974693
J Clin Endocrinol Metab. 2013 May;98(5):1971-81
pubmed: 23543660
Pharmacol Ther. 2015 Nov;155:22-35
pubmed: 26277280
Diabetes. 2008 Jun;57(6):1455-6
pubmed: 18511446
J Bone Miner Res. 2001 Jan;16(1):182-8
pubmed: 11149483
Int J Biochem Cell Biol. 2004 Dec;36(12):2503-18
pubmed: 15325588
Calcif Tissue Int. 2014 Feb;94(2):159-68
pubmed: 23907724
PLoS One. 2013 Oct 25;8(10):e77701
pubmed: 24204923
Autophagy. 2014;10(11):1965-77
pubmed: 25484092
Cancer Res. 2017 Mar 15;77(6):1453-1464
pubmed: 28108519
Oncotarget. 2015 Oct 27;6(33):34329-41
pubmed: 26455377