Adenovirus Vector-Based Vaccines Confer Maternal-Fetal Protection against Zika Virus Challenge in Pregnant IFN-αβR
Adenoviridae
/ genetics
Animals
Antibodies, Neutralizing
/ blood
Antibodies, Viral
/ blood
Cell Line
Chlorocebus aethiops
Disease Models, Animal
Female
Immunity, Maternally-Acquired
/ immunology
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Pregnancy
Receptor, Interferon alpha-beta
/ genetics
Vaccination
Vero Cells
Viral Vaccines
/ immunology
Zika Virus
/ immunology
Zika Virus Infection
/ immunology
ZIKV
adenovirus
mouse
pregnancy
vaccine
Journal
Cell host & microbe
ISSN: 1934-6069
Titre abrégé: Cell Host Microbe
Pays: United States
ID NLM: 101302316
Informations de publication
Date de publication:
13 11 2019
13 11 2019
Historique:
received:
03
11
2018
revised:
06
07
2019
accepted:
25
09
2019
pubmed:
2
11
2019
medline:
5
3
2020
entrez:
1
11
2019
Statut:
ppublish
Résumé
Maternal infection with Zika virus (ZIKV) can lead to microcephaly and other congenital abnormalities of the fetus. Although ZIKV vaccines that prevent or reduce viremia in non-pregnant mice have been described, a maternal vaccine that provides complete fetal protection would be desirable. Here, we show that adenovirus (Ad) vector-based ZIKV vaccines induce potent neutralizing antibodies that confer robust maternal and fetal protection against ZIKV challenge in pregnant, highly susceptible IFN-αβR
Identifiants
pubmed: 31668877
pii: S1931-3128(19)30525-6
doi: 10.1016/j.chom.2019.10.001
pmc: PMC6863051
mid: NIHMS1059135
pii:
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
Ifnar1 protein, mouse
0
Viral Vaccines
0
Receptor, Interferon alpha-beta
156986-95-7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
591-600.e4Subventions
Organisme : NIAID NIH HHS
ID : K08 AI135098
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007387
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI128751
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI124377
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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