Growth and differentiation factor 15 as a biomarker for mitochondrial myopathy.
Exercise
Growth and differentiation factor 15
Metabolic myopathy
Mitochondrial myopathy
Muscular dystrophy
Journal
Mitochondrion
ISSN: 1872-8278
Titre abrégé: Mitochondrion
Pays: Netherlands
ID NLM: 100968751
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
02
06
2019
revised:
03
09
2019
accepted:
02
10
2019
pubmed:
2
11
2019
medline:
24
2
2021
entrez:
1
11
2019
Statut:
ppublish
Résumé
We investigated if Growth and Differentiation Factor 15 (GDF-15) can be used as a biomarker to distinguish patients with mitochondrial myopathy from patients with other myopathies. Serum GDF-15 was measured in 28 patients with mitochondrial disease, 24 with metabolic myopathies, 27 with muscular dystrophy and 21 healthy controls. Our findings indicate that elevated GDF-15 can distinguish patients with mitochondrial myopathy from other myopathies, including metabolic myopathies. This suggests that increases in GDF-15 is specific to respiratory chain dysfunction rather than general metabolic dysfunction or muscle defect.
Identifiants
pubmed: 31669236
pii: S1567-7249(19)30144-8
doi: 10.1016/j.mito.2019.10.005
pii:
doi:
Substances chimiques
Biomarkers
0
GDF15 protein, human
0
Growth Differentiation Factor 15
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
35-41Informations de copyright
Copyright © 2019 Elsevier B.V. and Mitochondria Research Society. All rights reserved.