Curcumin protects purkinje neurons, ameliorates motor function and reduces cerebellar atrophy in rat model of cerebellar ataxia induced by 3-AP.
Animals
Atrophy
/ chemically induced
Cerebellar Ataxia
/ chemically induced
Cerebellum
/ drug effects
Curcumin
/ pharmacology
Disease Models, Animal
Electromyography
Male
Motor Activity
/ drug effects
Neuroprotective Agents
/ pharmacology
Purkinje Cells
/ drug effects
Pyridines
Rats
Rats, Sprague-Dawley
3-Acethylpyridine
Cerebellar ataxia
Curcumin
Neuroprotection
Purkinje cells
Journal
Journal of chemical neuroanatomy
ISSN: 1873-6300
Titre abrégé: J Chem Neuroanat
Pays: Netherlands
ID NLM: 8902615
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
13
07
2019
revised:
22
10
2019
accepted:
22
10
2019
pubmed:
2
11
2019
medline:
15
9
2020
entrez:
1
11
2019
Statut:
ppublish
Résumé
Cerebellar ataxias comprise a group of terminal illnesses with ataxia as the main symptom. Curcumin as a yellow polyphenol was extracted from the rhizome ofCurcuma longa. Owing to its antioxidant, anti-inflammatory, anti-fibrotic and anti-tumor features, curcumin is considered as a potential therapeutic agent. In this study, we aim to investigate the neuroprotective effects of oral administration of curcumin on a rat model of cerebellar ataxia induced by neurotoxin 3-acetylpyridine. The animals were randomly separated into three groups (control, 3-acetylpyridine, and curcumin + 3-acetylpyridine). Next, motor performance and muscle electromyography activity were assessed. Then, in the molecular part of the study, the anti-apoptotic role of curcumin in cerebellar ataxia and its relationship to protection of Purkinje cells were investigated. Curcumin treatment improved motor coordination and muscular activity, reduced cleaved caspase-3, and increased glutathione level in 3-AP-lesioned rats as well as total volumes of cerebellar granular and molecular layers. the present study implies that curcumin might have neuroprotective effects to counteract neurotoxicity of 3-AP-induced ataxia.
Sections du résumé
BACKGROUND
Cerebellar ataxias comprise a group of terminal illnesses with ataxia as the main symptom. Curcumin as a yellow polyphenol was extracted from the rhizome ofCurcuma longa. Owing to its antioxidant, anti-inflammatory, anti-fibrotic and anti-tumor features, curcumin is considered as a potential therapeutic agent.
AIM
In this study, we aim to investigate the neuroprotective effects of oral administration of curcumin on a rat model of cerebellar ataxia induced by neurotoxin 3-acetylpyridine.
METHODS
The animals were randomly separated into three groups (control, 3-acetylpyridine, and curcumin + 3-acetylpyridine). Next, motor performance and muscle electromyography activity were assessed. Then, in the molecular part of the study, the anti-apoptotic role of curcumin in cerebellar ataxia and its relationship to protection of Purkinje cells were investigated.
RESULTS
Curcumin treatment improved motor coordination and muscular activity, reduced cleaved caspase-3, and increased glutathione level in 3-AP-lesioned rats as well as total volumes of cerebellar granular and molecular layers.
CONCLUSION
the present study implies that curcumin might have neuroprotective effects to counteract neurotoxicity of 3-AP-induced ataxia.
Identifiants
pubmed: 31669431
pii: S0891-0618(19)30128-0
doi: 10.1016/j.jchemneu.2019.101706
pii:
doi:
Substances chimiques
Neuroprotective Agents
0
Pyridines
0
3-acetylpyridine
00QT8FX306
Curcumin
IT942ZTH98
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101706Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.