Membrane-anchored heat-shock protein 70 (Hsp70) in cancer.
Exosomal Hsp70
Hsp70 translocation
Membrane Hsp70
Targeting Hsp70
Journal
Cancer letters
ISSN: 1872-7980
Titre abrégé: Cancer Lett
Pays: Ireland
ID NLM: 7600053
Informations de publication
Date de publication:
28 01 2020
28 01 2020
Historique:
received:
16
08
2019
revised:
18
10
2019
accepted:
22
10
2019
pubmed:
2
11
2019
medline:
1
7
2020
entrez:
1
11
2019
Statut:
ppublish
Résumé
Hsp70 is a highly conserved and inducible heat shock protein that belongs to the HSP70 family of molecular chaperones and plays a central role in protein homeostasis. The main function of Hsp70 is to protect cells from physiological, pathological and environmental insults, as it assists an ATP-dependent manner the process of protein folding. Since Hsp70 provides critical cell survival functions, cancer cells are assumed to rely on this chaperone. Strong evidence suggests that Hsp70 is upregulated in different type of cancers and is involved in tumor growth, invasion, migration and resistance to anti-cancer therapy. Interestingly, this Hsp70 upregulation induces Hsp70 re-location into plasma membrane. In this review, the role of Hsp70 in cancer will be discussed focusing particularly on the extracellular membrane-bound Hsp70. The mechanism by which Hsp70 is translocated to plasma membrane of tumor cells and the recent discoveries of drugs targeting this Hsp70 in cancer therapy will be also highlighted.
Identifiants
pubmed: 31669516
pii: S0304-3835(19)30540-3
doi: 10.1016/j.canlet.2019.10.037
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
HSP70 Heat-Shock Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
134-141Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.